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Lifestyle modifications: coordinating the tRNA epitranscriptome with codon bias to adapt translation during stress responses

Author(s)
Chan, Cheryl; Begley, Thomas J.; Pham, Phuong M.; Dedon, Peter C
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Abstract
Cells adapt to stress by altering gene expression at multiple levels. Here, we propose a new mechanism regulating stress-dependent gene expression at the level of translation, with coordinated interplay between the tRNA epitranscriptome and biased codon usage in families of stress-response genes. In this model, auxiliary genetic information contained in synonymous codon usage enables regulation of codon-biased and functionally related transcripts by dynamic changes in the tRNA epitranscriptome. This model partly explains the association between synchronous stress-dependent epitranscriptomic marks and significant multi-codon usage skewing in families of translationally regulated transcripts. The model also predicts translational adaptation during viral infections.
Date issued
2018-12
URI
http://hdl.handle.net/1721.1/119843
Department
Massachusetts Institute of Technology. Department of Biological Engineering
Journal
Genome Biology
Publisher
Biomed Central Ltd
Citation
Chan, Cheryl et al. "Lifestyle modifications: coordinating the tRNA epitranscriptome with codon bias to adapt translation during stress responses." Genome Biology 19 (December 2018): 228 © 2018 The Author(s)
Version: Final published version
ISSN
1474-760X

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