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dc.contributor.authorYannas, Ioannis V
dc.contributor.authorTzeranis, Dimitrios
dc.contributor.authorSo, Peter T. C.
dc.date.accessioned2019-01-04T15:56:33Z
dc.date.available2019-01-04T15:56:33Z
dc.date.issued2017-12
dc.date.submitted2017-12
dc.identifier.issn2468-4511
dc.identifier.urihttp://hdl.handle.net/1721.1/119852
dc.description.abstractThis article is a review of current research on the mechanism of regeneration of skin and peripheral nerves based on use of collagen scaffolds, particularly the dermis regeneration template (DRT), which is widely used clinically. DRT modifies the normal wound healing process, converting it from wound closure by contraction and scar formation to closure by regeneration. DRT achieves this modification by blocking wound contraction, which spontaneously leads to cancellation of scar formation, a process secondary to contraction. Contraction blocking by DRT is the result of a dramatic phenotype change in contractile cells (myofibroblasts, MFB) which follows specific binding of integrins α1β1 and α2β1 onto hexapeptide ligands, probably GFOGER and GLOGER, that are naturally present on the surface of collagen fibers in DRT. The methodology of organ regeneration based on use of DRT has been recently extended from traumatized skin to diseased skin. Successful extension of the method to other organs in which wounds heal by contraction is highly likely though not yet attempted. This regenerative paradigm is much more advanced both in basic mechanistic understanding and clinical use than methods based on tissue culture or stem cells. It is also largely free of risk and has shown decisively lower morbidity and lower cost than organ transplantation. Keywords: Regeneration, Skin, Peripheral nerves, Phenotype change, Contraction blocking, Integrin-ligand interactionen_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (RO1 NS051320)en_US
dc.description.sponsorshipHorizon 2020 Framework Programme (European Commission) (Grant DLV-658850)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (5-P41-EB015871-28)en_US
dc.description.sponsorshipSingapore-MIT Alliance for Research and Technology (SMART)en_US
dc.description.sponsorshipHamamatsu Corporationen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/J.COBME.2017.12.002en_US
dc.rightsCreative Commons Attribution 4.0 International licenseen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.sourceElsevieren_US
dc.titleRegeneration mechanism for skin and peripheral nerves clarified at the organ and molecular scalesen_US
dc.typeArticleen_US
dc.identifier.citationYannas, Ioannis V., Dimitrios S. Tzeranis, and Peter T.C. So. “Regeneration Mechanism for Skin and Peripheral Nerves Clarified at the Organ and Molecular Scales.” Current Opinion in Biomedical Engineering 6 (June 2018): 1–7.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Mechanical Engineeringen_US
dc.contributor.mitauthorYannas, Ioannis V
dc.contributor.mitauthorTzeranis, Dimitrios
dc.contributor.mitauthorSo, Peter T. C.
dc.relation.journalCurrent Opinion in Biomedical Engineeringen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2019-01-04T14:31:30Z
dspace.orderedauthorsYannas, Ioannis V.; Tzeranis, Dimitrios S.; So, Peter T.C.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0003-0151-708X
dc.identifier.orcidhttps://orcid.org/0000-0003-4698-6488
mit.licensePUBLISHER_CCen_US


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