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dc.contributor.authorZheng, Cheng
dc.contributor.authorZhou, Renjie
dc.contributor.authorKuang, Cuifang
dc.contributor.authorZhao, Guangyuan
dc.contributor.authorYaqoob, Zahid
dc.contributor.authorSo, Peter T. C.
dc.date.accessioned2019-01-11T20:22:37Z
dc.date.available2019-01-11T20:22:37Z
dc.date.issued2017-03
dc.identifier.issn0146-9592
dc.identifier.issn1539-4794
dc.identifier.urihttp://hdl.handle.net/1721.1/120010
dc.description.abstractWe propose a novel common-path quantitative phase imaging (QPI) method based on a digital micromirror device (DMD). The DMD is placed in a plane conjugate to the objective back-aperture plane for the purpose of generating two plane waves thatilluminate the sample.Apinhole isused in the detection arm to filter one of the beams after sample to create a reference beam. Additionally, a transmission-type liquid crystal device, placed at the objective back-aperture plane, eliminates the specular reflection noise arising from all the "off" state DMD micromirrors, which is common in all DMD-based illuminations. We have demonstrated high sensitivity QPI, which has a measured spatial and temporal noise of 4.92 nm and 2.16 nm, respectively. Experiments with calibrated polystyrene beads illustrate the desired phase measurement accuracy. In addition, we have measured the dynamic height maps of red blood cell membrane fluctuations, showing the efficacy of the proposed system for live cell imaging. Most importantly, the DMD grants the system convenience in varying the interference fringe period on the camera to easily satisfy the pixel sampling conditions. This feature also alleviates the pinhole alignment complexity. We envision that the proposed DMD-based common-path QPI system will allow for system miniaturization and automation for a broader adaption.en_US
dc.description.sponsorshipNational Basic Research Program of China (973 Program) (2015CB352003)en_US
dc.description.sponsorshipNational Natural Science Foundation (China) (61335003)en_US
dc.description.sponsorshipNational Natural Science Foundation (China) (61427818)en_US
dc.description.sponsorshipNational Natural Science Foundation (China) (61378051)en_US
dc.description.sponsorshipNatural Science Foundation of Zhejiang Province (LR16F050001)en_US
dc.description.sponsorshipChina. Fundamental Research Funds for the Central Universities (2016FZA5002)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (1R01HL121386-01A1)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (9P41EB015871-26A1)en_US
dc.description.sponsorshipSingapore-MIT Alliance for Research and Technology (SMART)en_US
dc.description.sponsorshipOpen Foundation of the State Key Laboratory of Modern Optical Instrumentationen_US
dc.description.sponsorshipHamamatsu Corporationen_US
dc.publisherThe Optical Societyen_US
dc.relation.isversionofhttp://dx.doi.org/10.1364/OL.42.001448en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleDigital micromirror device-based common-path quantitative phase imagingen_US
dc.typeArticleen_US
dc.identifier.citationZheng, Cheng, Renjie Zhou, Cuifang Kuang, Guangyuan Zhao, Zahid Yaqoob, and Peter T. C. So. “Digital Micromirror Device-Based Common-Path Quantitative Phase Imaging.” Optics Letters 42, no. 7 (March 31, 2017): 1448. © 2017 Optical Society of America.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Mechanical Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Laser Biomedical Research Centeren_US
dc.contributor.mitauthorZhou, Renjie
dc.contributor.mitauthorYaqoob, Zahid
dc.contributor.mitauthorSo, Peter T. C.
dc.relation.journalOptics Lettersen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2019-01-04T13:25:47Z
dspace.orderedauthorsZheng, Cheng; Zhou, Renjie; Kuang, Cuifang; Zhao, Guangyuan; Yaqoob, Zahid; So, Peter T. C.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-4761-6641
dc.identifier.orcidhttps://orcid.org/0000-0003-4698-6488
mit.licenseOPEN_ACCESS_POLICYen_US


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