dc.contributor.author | Kuzniewska, Bozena | |
dc.contributor.author | Pena, Franciso X. | |
dc.contributor.author | Lei, Ding J. | |
dc.contributor.author | Nguyen, Shannon | |
dc.contributor.author | Dziembowska, Magdalena | |
dc.contributor.author | Jones, Kendrick | |
dc.contributor.author | Templet, Sebastian B. | |
dc.contributor.author | Zemoura, Khaled | |
dc.contributor.author | Hwang, Hongik | |
dc.contributor.author | Haensgen Saez, Henny M | |
dc.contributor.author | Saenz, Christopher | |
dc.contributor.author | Lewis, Michael C. | |
dc.contributor.author | Xu, Weifeng | |
dc.date.accessioned | 2019-02-08T16:47:32Z | |
dc.date.available | 2019-02-08T16:47:32Z | |
dc.date.issued | 2018-06 | |
dc.date.submitted | 2017-09 | |
dc.identifier.issn | 0027-8424 | |
dc.identifier.issn | 1091-6490 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/120292 | |
dc.description.abstract | Experience induces de novo protein synthesis in the brain and protein synthesis is required for long-term memory. It is important to define the critical temporal window of protein synthesis and identify newly synthesized proteins required for memory formation. Using a behavioral paradigm that temporally separates the contextual exposure from the association with fear, we found that protein synthesis during the transient window of context exposure is required for contextual memory formation. Among an array of putative activity-dependent translational neuronal targets tested, we identified one candidate, a schizophrenia-associated candidate mRNA, neurogranin (Ng, encoded by the Nrgn gene) responding to novel-context exposure. The Ng mRNA was recruited to the actively translating mRNA pool upon novel-context exposure, and its protein levels were rapidly increased in the hippocampus. By specifically blocking activity-dependent translation of Ng using virus-mediated molecular perturbation, we show that experience-dependent translation of Ng in the hippocampus is required for contextual memory formation. We further interrogated the molecular mechanism underlying the experience-dependent translation of Ng, and found that fragile-X mental retardation protein (FMRP) interacts with the 3′UTR of the Nrgn mRNA and is required for activity-dependent translation of Ng in the synaptic compartment and contextual memory formation. Our results reveal that FMRP-mediated, experience-dependent, rapid enhancement of Ng translation in the hippocampus during the memory acquisition enables durable context memory encoding. Keywords: hippocampus; contextual memory; dentate gyrus; ASD; schizophrenia | en_US |
dc.publisher | National Academy of Sciences (U.S.) | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1073/pnas.1716750115 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | PNAS | en_US |
dc.title | Rapid, experience-dependent translation of neurogranin enables memory encoding | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Jones, Kendrick J. et al. “Rapid, Experience-Dependent Translation of Neurogranin Enables Memory Encoding.” Proceedings of the National Academy of Sciences 115, 25 (June 2018): E5805–E5814 © 2018 National Academy of Sciences | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
dc.contributor.department | McGovern Institute for Brain Research at MIT | en_US |
dc.contributor.department | Picower Institute for Learning and Memory | en_US |
dc.contributor.mitauthor | Jones, Kendrick | |
dc.contributor.mitauthor | Templet, Sebastian B. | |
dc.contributor.mitauthor | Zemoura, Khaled | |
dc.contributor.mitauthor | Hwang, Hongik | |
dc.contributor.mitauthor | Haensgen Saez, Henny M | |
dc.contributor.mitauthor | Saenz, Christopher | |
dc.contributor.mitauthor | Lewis, Michael C. | |
dc.contributor.mitauthor | Xu, Weifeng | |
dc.relation.journal | Proceedings of the National Academy of Sciences | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dc.date.updated | 2019-02-08T16:06:46Z | |
dspace.orderedauthors | Jones, Kendrick J.; Templet, Sebastian; Zemoura, Khaled; Kuzniewska, Bozena; Pena, Franciso X.; Hwang, Hongik; Lei, Ding J.; Haensgen, Henny; Nguyen, Shannon; Saenz, Christopher; Lewis, Michael; Dziembowska, Magdalena; Xu, Weifeng | en_US |
dspace.embargo.terms | N | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-3857-8671 | |
dc.identifier.orcid | https://orcid.org/0000-0002-6363-9579 | |
dc.identifier.orcid | https://orcid.org/0000-0003-0096-2288 | |
mit.license | PUBLISHER_POLICY | en_US |