Demonstration of Triband Multi-Focal Imaging with Optical Coherence Tomography
Author(s)
Nam, Ahhyun Stephanie; Ren, Jian; Bouma, Brett E.; Vakoc, Benjamin J.; Nam, Ahhyun; Bouma, Brett E; Vakoc, Benjamin; ... Show more Show less
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We demonstrate an extended depth of focus optical coherence tomography (OCT) system based on the use of chromatic aberration to create displaced focal planes in the sample. The system uses a wavelength-swept source tuning over three spectral bands and three separate interferometers, each of which interfaces to a single illumination/collection fiber. The resulting three imaged volumes are merged in post-processing to generate an image with a larger depth of focus than is obtained from each band individually. The improvements are demonstrated in structural imaging of a porous phantom and a lipid-cleared murine brain, and by angiographic imaging of human skin. By using a coaxial approach with Gaussian beams, this approach enables an extended focus with relatively simple microscope optics and data-merging algorithms. Keywords: optical coherence tomography; multi-focal imaging; chromatic focal shift
Date issued
2018-11Department
Harvard University--MIT Division of Health Sciences and TechnologyJournal
Applied Sciences
Publisher
Multidisciplinary Digital Publishing Institute
Citation
Nam, Ahhyun et al. "Demonstration of Triband Multi-Focal Imaging with
Optical Coherence Tomography." Applied Sciences 8, 12 (November 2018): 2395 © 2018 The Authors
Version: Final published version
ISSN
2076-3417