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dc.contributor.authorTewari, Aneesha Gandhi
dc.contributor.authorStern, Sarah R.
dc.contributor.authorOderberg, Isaac Max
dc.contributor.authorReddien, Peter
dc.date.accessioned2019-03-07T15:48:29Z
dc.date.available2019-03-07T15:48:29Z
dc.date.issued2018-11
dc.date.submitted2018-09
dc.identifier.issn2211-1247
dc.identifier.urihttp://hdl.handle.net/1721.1/120794
dc.description.abstractThe fundamental requirements for regeneration are poorly understood. Planarians can robustly regenerate all tissues after injury, involving stem cells, positional information, and a set of cellular and molecular responses collectively called the “missing tissue” or “regenerative” response. follistatin, which encodes an extracellular Activin inhibitor, is required for the missing tissue response after head amputation and for subsequent regeneration. We found that follistatin is required for the missing tissue response regardless of the wound context, but causes regeneration failure only after head amputation. This head regeneration failure involves follistatin-mediated regulation of Wnt signaling at wounds and is not a consequence of a diminished missing tissue response. All tested contexts of regeneration, including head regeneration, could occur with a defective missing tissue response, but at a slower pace. Our findings suggest that major cellular and molecular programs induced specifically by large injuries function to accelerate regeneration but are dispensable for regeneration itself. In regenerative organisms, a large array of cellular responses are triggered at major injuries. However, which of these responses are fundamentally required for regeneration to occur remains unknown. Tewari et al. find that hallmark cellular and molecular responses induced uniquely at large injuries are dispensable for planarian regeneration. Keywords: regeneration; wound response; WnT signaling; TGF-β signaling; planarians; follistatinen_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant R01GM080639)en_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.celrep.2018.11.004en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourceElsevieren_US
dc.titleCellular and Molecular Responses Unique to Major Injury Are Dispensable for Planarian Regenerationen_US
dc.typeArticleen_US
dc.identifier.citationTewari, Aneesha G. et al. “Cellular and Molecular Responses Unique to Major Injury Are Dispensable for Planarian Regeneration.” Cell Reports 25, 9 (November 2018): 2577–2590 © 2018 The Author(s)en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.mitauthorTewari, Aneesha Gandhi
dc.contributor.mitauthorStern, Sarah R.
dc.contributor.mitauthorOderberg, Isaac Max
dc.contributor.mitauthorReddien, Peter
dc.relation.journalCell Reportsen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2019-02-26T14:05:58Z
dspace.orderedauthorsTewari, Aneesha G.; Stern, Sarah R.; Oderberg, Isaac M.; Reddien, Peter W.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0003-3422-1074
dc.identifier.orcidhttps://orcid.org/0000-0002-8436-4535
dc.identifier.orcidhttps://orcid.org/0000-0002-5569-333X
mit.licensePUBLISHER_CCen_US


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