MIT Libraries logoDSpace@MIT

MIT
View Item 
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies

Author(s)
Muir, Alexander; Danai, Laura V.; Vander Heiden, Matthew G.
Thumbnail
Downloaddmm035758.full.pdf (748.0Kb)
PUBLISHER_CC

Publisher with Creative Commons License

Creative Commons Attribution

Terms of use
Creative Commons Attribution 3.0 unported license https://creativecommons.org/licenses/by/3.0/
Metadata
Show full item record
Abstract
Cancers have an altered metabolism, and there is interest in understanding precisely how oncogenic transformation alters cellular metabolism and how these metabolic alterations can translate into therapeutic opportunities. Researchers are developing increasingly powerful experimental techniques to study cellular metabolism, and these techniques have allowed for the analysis of cancer cell metabolism, both in tumors and in ex vivo cancer models. These analyses show that, while factors intrinsic to cancer cells such as oncogenic mutations, alter cellular metabolism, cell-extrinsic microenvironmental factors also substantially contribute to the metabolic phenotype of cancer cells. These findings highlight that microenvironmental factors within the tumor, such as nutrient availability, physical properties of the extracellular matrix, and interactions with stromal cells, can influence the metabolic phenotype of cancer cells and might ultimately dictate the response to metabolically targeted therapies. In an effort to better understand and target cancer metabolism, this Review focuses on the experimental evidence that microenvironmental factors regulate tumor metabolism, and on the implications of these findings for choosing appropriate model systems and experimental approaches. Keywords\: Cancer, Cancer models, Metabolism, Microenvironment, Nutrient availability, Nutrient sensing
Date issued
2018-08
URI
http://hdl.handle.net/1721.1/120923
Department
Massachusetts Institute of Technology. Department of Biology; Koch Institute for Integrative Cancer Research at MIT
Journal
Disease Models & Mechanisms
Publisher
Company of Biologists
Citation
Muir, Alexander, Laura V. Danai, and Matthew G. Vander Heiden. “Microenvironmental Regulation of Cancer Cell Metabolism: Implications for Experimental Design and Translational Studies.” Disease Models & Mechanisms 11, no. 8 (August 1, 2018): dmm035758. © 2018 The Company of Biologists Ltd.
Version: Final published version
ISSN
1754-8403
1754-8411

Collections
  • MIT Open Access Articles

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

Login

Statistics

OA StatisticsStatistics by CountryStatistics by Department
MIT Libraries
PrivacyPermissionsAccessibilityContact us
MIT
Content created by the MIT Libraries, CC BY-NC unless otherwise noted. Notify us about copyright concerns.