Show simple item record

dc.contributor.authorRebhun, Carl B.
dc.contributor.authorMoult, Eric Michael
dc.contributor.authorNovais, Eduardo
dc.contributor.authorMoreira-Neto, Carlos
dc.contributor.authorPloner, Stefan B
dc.contributor.authorLouzada, Ricardo N.
dc.contributor.authorLee, Byungkun
dc.contributor.authorBaumal, Caroline R.
dc.contributor.authorFujimoto, James G
dc.contributor.authorDuker, Jay S.
dc.contributor.authorWaheed, Nadia K.
dc.contributor.authorFerrara, Daniela
dc.date.accessioned2019-07-05T15:40:43Z
dc.date.available2019-07-05T15:40:43Z
dc.date.issued2017-11
dc.date.submitted2017-06
dc.identifier.issn2164-2591
dc.identifier.urihttps://hdl.handle.net/1721.1/121496
dc.description.abstractPurpose: To use a novel optical coherence tomography angiography (OCTA) algorithm termed variable interscan time analysis (VISTA) to evaluate relative blood flow speeds in polypoidal choroidal vasculopathy (PCV). Methods: Prospective cross-sectional study enrolling patients with confirmed diagnosis of PCV. OCTA of the retina and choroid was obtained with a prototype swept-source OCT system. The acquired OCT volumes were centered on the branching vascular network (BVN) and polyps as determined by indocyanine-green angiography (ICGA). The relative blood flow speeds were characterized on VISTAOCTA. Results: Seven eyes from seven patients were evaluated. Swept-source OCTA enabled detailed enface visualization of the BVN and polyps in six eyes. VISTA-OCTA revealed variable blood flow speeds in different PCV lesion components of the same eye, with faster flow in the periphery of polyps and slower flow in the center of each polyp, as well as relatively slow flow in BVN when compared with retinal vessels. BVNs demonstrated relatively faster blood flow speeds in the larger trunk vessels and relatively slower speeds in the smaller vessels. Conclusions: Swept-source OCTA identifies polyps in most, but not all, PCV lesions. This limitation that may be related to relatively slow blood flow within the polyp, which may be below the OCTA’s sensitivity. VISTA-OCTA showed heterogeneous blood flow speeds within the polyps, which may indicate turbulent flow in the polyps. Translational Relevance: These results bring relevant insights into disease mechanisms that can account for the variable course of PCV, and can be relevant for diagnosis and management of patients with PCV. Keywords: OCTA; optical coherence tomography angiography; PCV; polypoidal choroidal vasculopathy; variable interscan time analysisen_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant R01-EY011289-29A)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant R44- EY022864)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant R01-CA075289-16)en_US
dc.description.sponsorshipAir Force Office of Scientific Research (Grant FA9550-15-1-0473)en_US
dc.description.sponsorshipAir Force Office of Scientific Research (Grant FA9550-12-1-0499)en_US
dc.language.isoen
dc.publisherAssociation for Research in Vision and Ophthalmology (ARVO)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1167/TVST.6.6.4en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourceAssociation for Research in Vision and Ophthalmology (ARVO)en_US
dc.titlePolypoidal Choroidal Vasculopathy on Swept-Source Optical Coherence Tomography Angiography with Variable Interscan Time Analysisen_US
dc.typeArticleen_US
dc.identifier.citationRebhun, Carl B. et al. "Polypoidal Choroidal Vasculopathy on Swept-Source Optical Coherence Tomography Angiography with Variable Interscan Time Analysis." Translational Vision Science & Technology 6, 6 (November 2017): 4 © 2017 The Authorsen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Scienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Research Laboratory of Electronicsen_US
dc.contributor.departmentMassachusetts Institute of Technology. Institute for Medical Engineering & Scienceen_US
dc.relation.journalTranslational Vision Science & Technologyen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2019-06-26T15:48:46Z
dspace.date.submission2019-06-26T15:48:47Z
mit.journal.volume6en_US
mit.journal.issue6en_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record