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The Definition, Rationale, and Effects of Thresholding in OCT Angiography

Author(s)
Cole, Emily D.; Moult, Eric Michael; Dang, Sabin; Choi, Woo Jhon; Ploner, Stefan B; Lee, ByungKun; Louzada, Ricardo; Novais, Eduardo; Schottenhamml, Julia Jennifer; Maier, Andreas; Fujimoto, James G; Waheed, Nadia K.; Duker, Jay S.; Husvogt, Lennart; ... Show more Show less
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Abstract
PURPOSE: To examine the definition, rationale, and effects of thresholding in OCT angiography (OCTA). DESIGN: A theoretical description of OCTA thresholding in combination with qualitative and quantitative analysis of the effects of OCTA thresholding in eyes from a retrospective case series. PARTICIPANTS: Four eyes were qualitatively examined: 1 from a 27-year-old control, 1 from a 78-year-old exudative age-related macular degeneration (AMD) patient, 1 from a 58-year-old myopic patient, and 1 from a 77-year-old nonexudative AMD patient with geographic atrophy (GA). One eye from a 75-year-old nonexudative AMD patient with GA was quantitatively analyzed. MAIN OUTCOME MEASURES: A theoretical thresholding model and a qualitative and quantitative description of the dependency of OCTA on thresholding level. RESULTS: Due to the presence of system noise, OCTA thresholding is a necessary step in forming OCTA images; however, thresholding can complicate the relationship between blood flow and OCTA signal. CONCLUSIONS: Thresholding in OCTA can cause significant artifacts, which should be considered when interpreting and quantifying OCTA images.
Date issued
2017-09
URI
https://hdl.handle.net/1721.1/121566
Department
Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Institute for Medical Engineering & Science; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Journal
Ophthalmology Retina
Publisher
Elsevier BV
Citation
Cole, Emily D., et al. “The Definition, Rationale, and Effects of Thresholding in OCT Angiography.” Ophthalmology Retina 1, no. 5 (September 2017): 435–47.
Version: Author's final manuscript
ISSN
2468-7219
2468-6530

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