The Definition, Rationale, and Effects of Thresholding in OCT Angiography
Author(s)Cole, Emily D.; Moult, Eric Michael; Dang, Sabin; Choi, Woo Jhon; Ploner, Stefan B; Lee, ByungKun; Louzada, Ricardo; Novais, Eduardo; Schottenhamml, Julia Jennifer; Husvogt, Lennart Alexander; Maier, Andreas; Fujimoto, James G; Waheed, Nadia K.; Duker, Jay S.; ... Show more Show less
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PURPOSE: To examine the definition, rationale, and effects of thresholding in OCT angiography (OCTA). DESIGN: A theoretical description of OCTA thresholding in combination with qualitative and quantitative analysis of the effects of OCTA thresholding in eyes from a retrospective case series. PARTICIPANTS: Four eyes were qualitatively examined: 1 from a 27-year-old control, 1 from a 78-year-old exudative age-related macular degeneration (AMD) patient, 1 from a 58-year-old myopic patient, and 1 from a 77-year-old nonexudative AMD patient with geographic atrophy (GA). One eye from a 75-year-old nonexudative AMD patient with GA was quantitatively analyzed. MAIN OUTCOME MEASURES: A theoretical thresholding model and a qualitative and quantitative description of the dependency of OCTA on thresholding level. RESULTS: Due to the presence of system noise, OCTA thresholding is a necessary step in forming OCTA images; however, thresholding can complicate the relationship between blood flow and OCTA signal. CONCLUSIONS: Thresholding in OCTA can cause significant artifacts, which should be considered when interpreting and quantifying OCTA images.
DepartmentHarvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Institute for Medical Engineering and Science; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Cole, Emily D., et al. “The Definition, Rationale, and Effects of Thresholding in OCT Angiography.” Ophthalmology Retina 1, no. 5 (September 2017): 435–47.
Author's final manuscript