| dc.contributor.author | Bogorad, Roman | |
| dc.contributor.author | Yin, Hao | |
| dc.contributor.author | Anderson, Daniel Griffith | |
| dc.date.accessioned | 2019-08-19T13:14:26Z | |
| dc.date.available | 2019-08-19T13:14:26Z | |
| dc.date.issued | 2017-11-14 | |
| dc.identifier.issn | 1538-4101 | |
| dc.identifier.issn | 1551-4005 | |
| dc.identifier.uri | https://hdl.handle.net/1721.1/121999 | |
| dc.description.abstract | By performing nine genome-wide microRNA (miRNA) screens, we recently uncovered a new class of miRNAs, which target multiple cyclins and cyclin-dependent kinases (CDKs). Systemic delivery of selected cell cycle-targeting miRNAs to mouse xenograft models resulted in potent anti-tumorigenic effects without affecting animals' health. Here, we provide an in-depth description of our miRNA screening methodology, analyses of selected cell cycle-targeting miRNAs, and discuss why miRNA therapy might be a viable therapeutic option for cancer patients. | en_US |
| dc.language.iso | en | |
| dc.publisher | Informa UK Limited | en_US |
| dc.relation.isversionof | 10.1080/15384101.2017.1380132 | en_US |
| dc.rights | Creative Commons Attribution-NonCommercial-NoDerivs License | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
| dc.source | Taylor & Francis | en_US |
| dc.subject | Developmental Biology | en_US |
| dc.subject | Cell Biology | en_US |
| dc.subject | Molecular Biology | en_US |
| dc.title | Identification of cell cycle-targeting microRNAs through genome-wide screens | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Hydbringa, Per, Yinan Wang, Roman L. Bogorad, Hao Yin, Daniel G. Andersond, Cheng Li, and Piotr Sicinski. "Identification of cell cycle-targeting microRNAs through genome-wide screens." Cell cycle, 16, no. 23 (Nov. 2017): pp. 2241-2248. © 2017 The Author(s) | en_US |
| dc.contributor.department | Harvard University--MIT Division of Health Sciences and Technology | en_US |
| dc.contributor.department | Koch Institute for Integrative Cancer Research at MIT | en_US |
| dc.relation.journal | Cell cycle | en_US |
| dc.eprint.version | Final published version | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dc.date.updated | 2019-08-09T13:22:07Z | |
| dspace.date.submission | 2019-08-09T13:22:08Z | |
| mit.journal.volume | 16 | en_US |
| mit.journal.issue | 23 | en_US |
