MIT Libraries logoDSpace@MIT

MIT
View Item 
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Reduction of measurement noise in a continuous glucose monitor by coating the sensor with a zwitterionic polymer

Author(s)
Xie, Xi; Doloff, Joshua C; Yesilyurt, Volkan; Sadraei, Atieh; McGarrigle, James J.; Omami, Mustafa; Veiseh, Omid; Farah, Shady; Isa, Douglas; Ghani, Sofia; Joshi, Ira; Vegas, Arturo; Li, Jie; Wang, Weiheng; Bader, Andrew; Tam, Hok Hei; Tao, Jun; Chen, Hui-jiuan; Yang, Boru; Williamson, Katrina Ann; Oberholzer, Jose; Langer, Robert S; Anderson, Daniel Griffith; ... Show more Show less
Thumbnail
DownloadAccepted version (2.955Mb)
Terms of use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Metadata
Show full item record
Abstract
© 2018, Nature Publishing Group. All rights reserved. Continuous glucose monitors (CGMs), used by patients with diabetes mellitus, can autonomously track fluctuations in blood glucose over time. However, the signal produced by CGMs during the initial recording period following sensor implantation contains substantial noise, requiring frequent recalibration via finger-prick tests. Here, we show that coating the sensor with a zwitterionic polymer, found via a combinatorial chemistry approach, significantly reduces signal noise and improves CGM performance. We evaluated the polymer-coated sensors in mice as well as in healthy and diabetic non-human primates, and show that the sensors accurately record glucose levels without the need for recalibration. We also show that the coated sensors significantly abrogated immune responses, as indicated by histology, fluorescent whole-body imaging of inflammation-associated protease activity and gene expression of inflammation markers. The polymer coating may allow CGMs to become standalone measuring devices.
Date issued
2018-07-30
URI
https://hdl.handle.net/1721.1/122291
Department
Koch Institute for Integrative Cancer Research at MIT; Massachusetts Institute of Technology. Department of Chemical Engineering; Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Publisher
Springer Science and Business Media LLC
Citation
Xie, Xi, Doloff, Joshua C, Yesilyurt, Volkan, Sadraei, Atieh, McGarrigle, James J. et al. 2018. "Reduction of measurement noise in a continuous glucose monitor by coating the sensor with a zwitterionic polymer." 2 (12).
Version: Author's final manuscript
ISSN
2157-846X

Collections
  • MIT Open Access Articles

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

Login

Statistics

OA StatisticsStatistics by CountryStatistics by Department
MIT Libraries
PrivacyPermissionsAccessibilityContact us
MIT
Content created by the MIT Libraries, CC BY-NC unless otherwise noted. Notify us about copyright concerns.