Dynamic pathway regulation: recent advances and methods of construction
Author(s)Tan, Sue Zanne; Prather, Kristala L
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Microbial cell factories are a renewable source for the production of biofuels and valuable chemicals. Dynamic pathway regulation has proved successful in improving production of molecules by balancing flux between growth of cells and production of metabolites. Systems for autonomous induction of pathway regulation are increasingly being developed, which include metabolite responsive promoters, biosensors, and quorum sensing systems. Since engineering such systems are dependent on the available methods for controlling protein abundance in the desired host, we review recent tools used for gene repression at the transcriptional, post-transcriptional and post-translational levels in Escherichia coli and Saccharomyces cerevisiae. These approaches may facilitate pathway engineering for biofuel and biochemical production.
Current Opinion in Chemical Biology
Tan, Sue Zanne and Kristala L. J. Prather. "Dynamic pathway regulation: recent advances and methods of construction." Current Opinion in Chemical Biology 41 (December 2017): 28-35 © 2017 Elsevier Ltd
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