| dc.contributor.author | Chyan, Wen | |
| dc.contributor.author | Kilgore, Henry R. | |
| dc.contributor.author | Raines, Ronald T | |
| dc.date.accessioned | 2020-01-22T21:54:37Z | |
| dc.date.available | 2020-01-22T21:54:37Z | |
| dc.date.issued | 2018-04 | |
| dc.date.submitted | 2018-03 | |
| dc.identifier.issn | 1043-1802 | |
| dc.identifier.issn | 1520-4812 | |
| dc.identifier.uri | https://hdl.handle.net/1721.1/123546 | |
| dc.description.abstract | Dextrans are a versatile class of polysaccharides with applications that span medicine, cell biology, food science, and consumer goods. Here, we report on a new type of large monofunctionalized dextran that exhibits unusual properties: efficient cytosolic and nuclear uptake. This dextran permeates various human cell types without the use of transfection agents, electroporation, or membrane perturbation. Cellular uptake occurs primarily through active transport via receptor-mediated processes. These monofunctionalized dextrans could serve as intracellular delivery platforms for drugs or other cargos. Keywords: carbohydrates; fluorescence; endocytosis; probes; conjugate acid-base pairs | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Grant R01 GM044783) | en_US |
| dc.language.iso | en | |
| dc.publisher | American Chemical Society (ACS) | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1021/acs.bioconjchem.8b00198 | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | PMC | en_US |
| dc.title | Cytosolic Uptake of Large Monofunctionalized Dextrans | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Cyan, Wen et al. "Cytosolic Uptake of Large Monofunctionalized Dextrans." Bioconjugate Chemistry 29, 6 (April 2018): 1942-1949 © 2018 American Chemical Society | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
| dc.relation.journal | Bioconjugate Chemistry | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dc.date.updated | 2020-01-06T18:42:43Z | |
| dspace.date.submission | 2020-01-06T18:42:46Z | |
| mit.journal.volume | 29 | en_US |
| mit.journal.issue | 6 | en_US |
| mit.metadata.status | Complete | |
