MIT Libraries logoDSpace@MIT

MIT
View Item 
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Bioinorganic Explorations of Zn(II) Sequestration by Human S100 Host-Defense Proteins

Author(s)
Cunden, Lisa Stephanie; Nolan, Elizabeth Marie
Thumbnail
DownloadAccepted version (1010.Kb)
Terms of use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Metadata
Show full item record
Abstract
The human innate immune system launches a metal-withholding response to starve invading microbial pathogens of essential metal nutrients. Zn(II)-sequestering proteins of the human S100 family contribute to this process and include calprotectin (CP, S100A8/S100A9 oligomer, calgranulin A/B oligomer), S100A12 (calgranulin C), and S100A7 (psoriasin). This Perspective highlights recent advances in the Zn(II) coordination chemistry of these three proteins, as well as select studies that evaluate Zn(II) sequestration as an antimicrobial mechanism. Keywords: immunology; peptides and proteins; metals; monomersIons
Date issued
2018-01
URI
https://hdl.handle.net/1721.1/123659
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Biochemistry
Publisher
American Chemical Society (ACS)
Citation
Cunden, Lisa S., and Elizabeth M. Nolan. "Bioinorganic Explorations of Zn(II) Sequestration by Human S100 Host-Defense Proteins." Biochemistry 57, 11 (January 2018): 1673-1680 © 2018 American Chemical Society
Version: Author's final manuscript
ISSN
0006-2960
1520-4995

Collections
  • MIT Open Access Articles

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

Login

Statistics

OA StatisticsStatistics by CountryStatistics by Department
MIT Libraries
PrivacyPermissionsAccessibilityContact us
MIT
Content created by the MIT Libraries, CC BY-NC unless otherwise noted. Notify us about copyright concerns.