Bioinorganic Explorations of Zn(II) Sequestration by Human S100 Host-Defense Proteins

Author(s)
Cunden, Lisa Stephanie; Nolan, Elizabeth Marie
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Abstract
The human innate immune system launches a metal-withholding response to starve invading microbial pathogens of essential metal nutrients. Zn(II)-sequestering proteins of the human S100 family contribute to this process and include calprotectin (CP, S100A8/S100A9 oligomer, calgranulin A/B oligomer), S100A12 (calgranulin C), and S100A7 (psoriasin). This Perspective highlights recent advances in the Zn(II) coordination chemistry of these three proteins, as well as select studies that evaluate Zn(II) sequestration as an antimicrobial mechanism. Keywords: immunology; peptides and proteins; metals; monomersIons
Date issued
2018-01
URI
https://hdl.handle.net/1721.1/123659
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Biochemistry
Publisher
American Chemical Society (ACS)
Citation
Cunden, Lisa S., and Elizabeth M. Nolan. "Bioinorganic Explorations of Zn(II) Sequestration by Human S100 Host-Defense Proteins." Biochemistry 57, 11 (January 2018): 1673-1680 © 2018 American Chemical Society
Version: Author's final manuscript
ISSN
0006-2960
1520-4995
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