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dc.contributor.authorSchall, Jennifer M.
dc.contributor.authorCapellades Mendez, Gerard
dc.contributor.authorMandur, Jasdeep S.
dc.contributor.authorBraatz, Richard D.
dc.contributor.authorMyerson, Allan S.
dc.date.accessioned2020-02-28T16:31:07Z
dc.date.available2020-02-28T16:31:07Z
dc.date.issued2019-08
dc.date.submitted2019-05
dc.identifier.issn1083-6160
dc.identifier.issn1520-586X
dc.identifier.urihttps://hdl.handle.net/1721.1/123883
dc.description.abstractCombined cooling and antisolvent crystallization enables crystallization of many pharmaceutical products, but its process design typically neglects solvent composition influences on crystallization kinetics. This paper evaluates the influence of solvent-dependent nucleation and growth kinetics on the design of optimal, multistage mixed-suspension, mixed-product removal (MSMPR) crystallization cascades. The ability to independently select temperature and solvent compositions in each stage of the cascade serves to greatly expand the attainable region for a two-stage cascade, with diminishing returns for additional stages. Failure to include solvent-dependent kinetics can result in simulating incorrect attainable regions, active pharmaceutical ingredient (API) yields, and crystal size distributions. This work also demonstrates that commonly employed crystallization process design heuristics, such as equal antisolvent addition and decreasing temperature in successive stages, can result in suboptimal process design if kinetics are strongly solvent dependent. Keyword: Crystals; Crystallization; Solvents; Nucleation kineticsen_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant 1122374)en_US
dc.publisherAmerican Chemical Society (ACS)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1021/acs.oprd.9b00244en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourceACSen_US
dc.titleIncorporating Solvent-Dependent Kinetics To Design a Multistage, Continuous, Combined Cooling/Antisolvent Crystallization Processen_US
dc.typeArticleen_US
dc.identifier.citationSchall, Jennifer M. et al. "Incorporating Solvent-Dependent Kinetics To Design a Multistage, Continuous, Combined Cooling/Antisolvent Crystallization Process." Organic Process Research and Development, 23 9, (August 2019): 1960-1969. © 2019 American Chemical Societyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.relation.journalOrganic Process Research and Developmenten_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.date.submission2019-11-25T20:03:34Z
mit.journal.volume23en_US
mit.journal.issue9en_US
mit.licenseOPEN_ACCESS_POLICY


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