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dc.contributor.authorSun, Hui
dc.contributor.authorMarelli, Benedetto
dc.date.accessioned2020-03-06T19:01:39Z
dc.date.available2020-03-06T19:01:39Z
dc.date.issued2020-01
dc.date.submitted2019-11
dc.identifier.issn2041-1723
dc.identifier.urihttps://hdl.handle.net/1721.1/124025
dc.description.abstractDespite advances in directing the assembly of biomacromolecules into well-defined nanostructures, leveraging pathway complexity of molecular disorder to order transition while bridging materials fabrication from nano- to macroscale remains a challenge. Here, we present templated crystallization of structural proteins to nanofabricate hierarchically structured materials up to centimeter scale, using silk fibroin as an example. The process involves the use of ordered peptide supramolecular assemblies as templates to direct the folding and assembly of silk fibroin into nanofibrillar structures. Silk polymorphs can be engineered by varying the peptide seeds used. Modulation of the relative concentration between silk fibroin and peptide seeds, silk fibroin molecular weight and pH allows control over nanofibrils morphologies and mechanical properties. Finally, facile integration of the bottom-up templated crystallization with emerging top-down techniques enables the generation of macroscopic nanostructured materials with potential applications in information storage/encryption, surface functionalization, and printable three-dimensional constructs of customized architecture and controlled anisotropy.en_US
dc.description.sponsorshipUnited States. Office of Naval Research (Award N000141812258)en_US
dc.description.sponsorshipNational Science Foundation (Award CMMI-1752172)en_US
dc.language.isoen
dc.publisherSpringer Science and Business Media LLCen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/s41467-019-14257-0en_US
dc.rightsCreative Commons Attribution 4.0 International licenseen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.sourceNatureen_US
dc.titlePolypeptide templating for designer hierarchical materialsen_US
dc.typeArticleen_US
dc.identifier.citationSun, Hui and Benedetto Marelli. "Polypeptide templating for designer hierarchical materials." Nature Communicatons 11, 1 (January 2020): 351 © 2020 The Author(s)en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Civil and Environmental Engineeringen_US
dc.relation.journalNature Communicationsen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2020-03-05T13:54:27Z
dspace.date.submission2020-03-05T13:54:30Z
mit.journal.volume11en_US
mit.journal.issue1en_US
mit.licensePUBLISHER_CC


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