3D structural patterns in scalable, elastomeric scaffolds guide engineered tissue architecture

Author(s)
Kolewe, Martin E.; Park, Hyoungshin; Gray, Caprice; Ye, Xiaofeng; Langer, Robert; ... Show more
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Abstract
Microfabricated elastomeric scaffolds with 3D structural patterns are created by semiautomated layer-by-layer assembly of planar polymer sheets with through-pores. The mesoscale interconnected pore architectures governed by the relative alignment of layers are shown to direct cell and muscle-like fiber orientation in both skeletal and cardiac muscle, enabling scale up of tissue constructs towards clinically relevant dimensions. ©2013
Date issued
2013-08
URI
https://hdl.handle.net/1721.1/124515
Department
Harvard University--MIT Division of Health Sciences and Technology
Journal
Advanced materials
Publisher
Wiley
Citation
Kolewe, Martin E., et al., "3D structural patterns in scalable, elastomeric scaffolds guide engineered tissue architecture." Advanced materials 25, 32 (August 2013): p. 4459-65 doi 10.1002/ADMA.201301016 ©2013 Author(s)
Version: Author's final manuscript
ISSN
0966-2979
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