Arylation chemistry for bioconjugation
Author(s)Zhang, Chi; Vinogradova, Ekaterina V.; Spokoyny, Alexander M.; Buchwald, Stephen Leffler; Pentelute, Bradley L.
MetadataShow full item record
Bioconjugation chemistry has been used to prepare modified biomolecules with functions beyond what nature intended. Central to these techniques is the development of highly efficient and selective bioconjugation reactions that operate under mild, biomolecule compatible conditions. Methods that form a nucleophile–sp 2 carbon bond show promise for creating bioconjugates with new modifications, sometimes resulting in molecules with unparalleled functions. Here we outline and review sulfur, nitrogen, selenium, oxygen, and carbon arylative bioconjugation strategies and their applications to modify peptides, proteins, sugars, and nucleic acids. ©2019
DepartmentMassachusetts Institute of Technology. Department of Chemistry
Angewandte Chemie. International edition in English
Zhang, Chi, et al., "Arylation chemistry for bioconjugation." Angewandte Chemie. International edition in English 58, 15 (November 2018): no. 4810 doi 10.1002/ANIE.201806009 ©2018 Author(s)
Author's final manuscript