Impact of oncogenic pathways on evasion of antitumour immune responses
Author(s)
Spranger, Stefani
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Immunotherapeutic interventions are showing effectiveness across a wide range of cancer types, but only a subset of patients shows clinical response to therapy. Responsiveness to checkpoint blockade immunotherapy is favoured by the presence of a local, CD8⁺ T cell-based immune response within the tumour microenvironment. As molecular analyses of tumours containing or lacking a productive CD8⁺ T cell infiltrate are being pursued, increasing evidence is indicating that activation of oncogenic pathways in tumour cells can impair induction or execution of a local antitumour immune response. This Review summarizes our current knowledge of the influence of oncogenic effects on evasion of antitumour immunity.
Date issued
2018-01-12Department
Massachusetts Institute of Technology. Department of Biology; Koch Institute for Integrative Cancer Research at MITJournal
Nature reviews. Cancer
Publisher
Springer Science and Business Media LLC
Citation
Spranger, Stefani and Thomas F. Gajewski. "Impact of oncogenic pathways on evasion of antitumour immune responses." Nature reviews. Cancer 18 (2018): 139-147 © 2018 The Author(s)
Version: Author's final manuscript
ISSN
1474-175X
1474-1768
Keywords
Cancer Research, Oncology