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dc.contributor.authorBruggeman, Joost P.
dc.contributor.authorBettinger, Christopher J.
dc.contributor.authorLanger, Robert
dc.date.accessioned2020-04-16T13:16:18Z
dc.date.available2020-04-16T13:16:18Z
dc.date.issued2010-08
dc.date.submitted2009-08
dc.identifier.issn1549-3296
dc.identifier.urihttps://hdl.handle.net/1721.1/124682
dc.description.abstractBiodegradable elastomers based on polycondensation reactions of xylitol with sebacic acid, referred to as poly(xylitol sebacate) (PXS) elastomers have recently been developed. We describe the in vivo behavior of PXS elastomers. Four PXS elastomers were synthesized, characterized, and compared with poly(L-lactic-co-glycolic acid) (PLGA). PXS elastomers displayed a high level of structural integrity and form stability during degradation. The in vivo half-life ranged from approximately 3 to 52 weeks. PXS elastomers exhibited increased biocompatibility compared with PLGA implants. Keywords: biomaterial; elastomer; biocompatibility; degradation; poly(xylitol sebacate; xylitolen_US
dc.description.sponsorshipNational Institute of Health (Grant HL060435)en_US
dc.description.sponsorshipCharles Stark Draper Laboratory Fellowshipen_US
dc.language.isoen
dc.publisherWiley-Blackwellen_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/jbm.a.32733en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleBiodegradable xylitol-based elastomers: In vivo behavior and biocompatibilityen_US
dc.typeArticleen_US
dc.identifier.citationBruggeman, Joost P., Bettingera, Christopher J. and Langera, Robert. "Biodegradable xylitol-based elastomers: In vivo behavior and biocompatibility." Journal of Biomedical Materials Research 95A, 1 (October 2010): 92-104 © 2010 Wiley Periodicals.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.contributor.departmentCharles Stark Draper Laboratoryen_US
dc.relation.journalJournal of Biomedical Materials Researchen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2019-08-22T18:36:13Z
dspace.date.submission2019-08-22T18:36:15Z
mit.journal.volume95Aen_US
mit.journal.issue1en_US


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