Probing the brain with molecular fMRI
Author(s)Ghosh, Souparno; Harvey, Peter; Simon, Jacob Cyert; Jasanoff, Alan
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One of the greatest challenges of modern neuroscience is to incorporate our growing knowledge of molecular and cellular-scale physiology into integrated, organismic-scale models of brain function in behavior and cognition. Molecular-level functional magnetic resonance imaging (molecular fMRI) is a new technology that can help bridge these scales by mapping defined microscopic phenomena over large, optically inaccessible regions of the living brain. In this review, we explain how MRI-detectable imaging probes can be used to sensitize noninvasive imaging to mechanistically significant components of neural processing. We discuss how a combination of innovative probe design, advanced imaging methods, and strategies for brain delivery can make molecular fMRI an increasingly successful approach for spatiotemporally resolved studies of diverse neural phenomena, perhaps eventually in people.
DepartmentMassachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Nuclear Science and Engineering; Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Current Opinion in Neurobiology
Ghosh, Souparno, et al. “Probing the Brain with Molecular FMRI.” Current Opinion in Neurobiology 50 (June 2018): 201–10.
Author's final manuscript