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dc.contributor.authorWang, Jing
dc.contributor.authorNarain, Devika
dc.contributor.authorHosseini, Eghbal A.
dc.contributor.authorJazayeri, Mehrdad
dc.date.accessioned2020-04-21T18:34:38Z
dc.date.available2020-04-21T18:34:38Z
dc.date.issued2017-12
dc.date.submitted2017-06
dc.identifier.issn1097-6256
dc.identifier.issn1546-1726
dc.identifier.urihttps://hdl.handle.net/1721.1/124769
dc.description.abstractMusicians can perform at different tempos, speakers can control the cadence of their speech, and children can flexibly vary their temporal expectations of events. To understand the neural basis of such flexibility, we recorded from the medial frontal cortex of nonhuman primates trained to produce different time intervals with different effectors. Neural responses were heterogeneous, nonlinear, and complex, and they exhibited a remarkable form of temporal invariance: firing rate profiles were temporally scaled to match the produced intervals. Recording from downstream neurons in the caudate and from thalamic neurons projecting to the medial frontal cortex indicated that this phenomenon originates within cortical networks. Recurrent neural network models trained to perform the task revealed that temporal scaling emerges from nonlinearities in the network and that the degree of scaling is controlled by the strength of external input. These findings demonstrate a simple and general mechanism for conferring temporal flexibility upon sensorimotor and cognitive functions.en_US
dc.description.sponsorshipNetherlands Scientific Organization (Rubicon Grant 2015/446-14-008)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (NINDS-NS078127)en_US
dc.language.isoen
dc.publisherSpringer Natureen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/S41593-017-0028-6en_US
dc.rightsCreative Commons Attribution 4.0 International licenseen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.sourceNatureen_US
dc.titleFlexible timing by temporal scaling of cortical responsesen_US
dc.typeArticleen_US
dc.identifier.citationWang, Jing, et al. “Flexible Timing by Temporal Scaling of Cortical Responses.” Nature Neuroscience 21, 1 (January 2018): 102–10. © 2017 The Authorsen_US
dc.contributor.departmentMcGovern Institute for Brain Research at MITen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.relation.journalNature Neuroscienceen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2019-10-02T16:20:19Z
dspace.date.submission2019-10-02T16:20:30Z
mit.journal.volume21en_US
mit.journal.issue1en_US


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