Helicobacter species are potent drivers of colonic T cell responses in homeostasis and inflammation
Author(s)
Shen, Zeli; Fox, James G.
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Specific gut commensal bacteria improve host health by eliciting mutualistic regulatory T (T[subscript reg]) cell responses. However, the bacteria that induce effector T (T[subscript eff]) cells during inflammation are unclear. We addressed this by analyzing bacterial-reactive T cell receptor (TCR) transgenic cells and TCR repertoires in a murine colitis model. Unexpectedly, we found that mucosal-associated Helicobacter species triggered both T[subscript reg] cell responses during homeostasis and T[subscript eff] cell responses during colitis, as suggested by an increased overlap between the T[subscript eff]/T[subscript reg] TCR repertoires with colitis. Four of six T[subscript reg] TCRs tested recognized mucosal-associated Helicobacter species in vitro and in vivo. By contrast, the marked expansion of luminal Bacteroides species seen during colitis did not trigger a commensurate T[subscript eff] cell response. Unlike other T[subscript reg] cell-inducing bacteria, Helicobacter species are known pathobionts and cause disease in immunodeficient mice. Thus, our study suggests a model in which mucosal bacteria elicit context-dependent T[subscript reg] or T[subscript eff] cell responses to facilitate intestinal tolerance or inflammation. ©2017
Date issued
2017-07Department
Massachusetts Institute of Technology. Division of Comparative Medicine; Massachusetts Institute of Technology. Department of Biological EngineeringJournal
Science immunology
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Chai, Jiani N., et al., "Helicobacter species are potent drivers of colonic T cell responses in homeostasis and inflammation." Science immunology 2, 13 (July 2017): no. eaal5068 doi 10.1126/SCIIMMUNOL.AAL5068 ©2017 Author(s)
Version: Author's final manuscript
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2470-9468
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