dc.contributor.author | Shen, Zeli | |
dc.contributor.author | Fox, James G. | |
dc.date.accessioned | 2020-04-22T12:49:17Z | |
dc.date.available | 2020-04-22T12:49:17Z | |
dc.date.issued | 2019-11-18 | |
dc.identifier.issn | 0027-8424 | |
dc.identifier.issn | 1091-6490 | |
dc.identifier.uri | https://hdl.handle.net/1721.1/124784 | |
dc.description.abstract | Intestinal innate lymphoid cells (ILCs) contribute to the protective immunity and homeostasis of the gut, and the microbiota are critically involved in shaping ILC function. However, the role of the gut microbiota in regulating ILC development and maintenance still remains elusive. Here, we identified opposing effects on ILCs by two Helicobacter species, Helicobacter apodemus and Helicobacter typhlonius, isolated from immunocompromised mice. We demonstrated that the introduction of both Helicobacter species activated ILCs and induced gut inflammation; however, these Helicobacter species negatively regulated RORγt+ group 3 ILCs (ILC3s), especially T-bet+ ILC3s, and diminished their proliferative capacity. Thus, these findings underscore a previously unknown dichotomous regulation of ILC3s by Helicobacter species, and may serve as a model for further investigations to elucidate the host–microbe interactions that critically sustain the maintenance of intestinal ILC3s. | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) ( Instrumentation Grant 1S10 OD021676-01) | en_US |
dc.language.iso | en | |
dc.publisher | Proceedings of the National Academy of Sciences | en_US |
dc.relation.isversionof | 10.1073/pnas.1908128116 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | PNAS | en_US |
dc.subject | Multidisciplinary | en_US |
dc.title | Dichotomous regulation of group 3 innate lymphoid cells by nongastric Helicobacter species | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Bostick, John W. et al. “Dichotomous regulation of group 3 innate lymphoid cells by nongastric Helicobacter species.” Proceedings of the National Academy of Sciences of the United States of America 116 (2019): 24760-24769 © 2019 The Author(s) | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Division of Comparative Medicine | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
dc.relation.journal | Proceedings of the National Academy of Sciences of the United States of America | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dc.date.updated | 2020-03-06T14:47:47Z | |
dspace.date.submission | 2020-03-06T14:47:49Z | |
mit.journal.volume | 116 | en_US |
mit.journal.issue | 49 | en_US |
mit.license | PUBLISHER_POLICY | |
mit.metadata.status | Complete | |