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dc.contributor.authorShen, Zeli
dc.contributor.authorFox, James G.
dc.date.accessioned2020-04-22T12:49:17Z
dc.date.available2020-04-22T12:49:17Z
dc.date.issued2019-11-18
dc.identifier.issn0027-8424
dc.identifier.issn1091-6490
dc.identifier.urihttps://hdl.handle.net/1721.1/124784
dc.description.abstractIntestinal innate lymphoid cells (ILCs) contribute to the protective immunity and homeostasis of the gut, and the microbiota are critically involved in shaping ILC function. However, the role of the gut microbiota in regulating ILC development and maintenance still remains elusive. Here, we identified opposing effects on ILCs by two Helicobacter species, Helicobacter apodemus and Helicobacter typhlonius, isolated from immunocompromised mice. We demonstrated that the introduction of both Helicobacter species activated ILCs and induced gut inflammation; however, these Helicobacter species negatively regulated RORγt+ group 3 ILCs (ILC3s), especially T-bet+ ILC3s, and diminished their proliferative capacity. Thus, these findings underscore a previously unknown dichotomous regulation of ILC3s by Helicobacter species, and may serve as a model for further investigations to elucidate the host–microbe interactions that critically sustain the maintenance of intestinal ILC3s.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) ( Instrumentation Grant 1S10 OD021676-01)en_US
dc.language.isoen
dc.publisherProceedings of the National Academy of Sciencesen_US
dc.relation.isversionof10.1073/pnas.1908128116en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourcePNASen_US
dc.subjectMultidisciplinaryen_US
dc.titleDichotomous regulation of group 3 innate lymphoid cells by nongastric Helicobacter speciesen_US
dc.typeArticleen_US
dc.identifier.citationBostick, John W. et al. “Dichotomous regulation of group 3 innate lymphoid cells by nongastric Helicobacter species.” Proceedings of the National Academy of Sciences of the United States of America 116 (2019): 24760-24769 © 2019 The Author(s)en_US
dc.contributor.departmentMassachusetts Institute of Technology. Division of Comparative Medicineen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.relation.journalProceedings of the National Academy of Sciences of the United States of Americaen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2020-03-06T14:47:47Z
dspace.date.submission2020-03-06T14:47:49Z
mit.journal.volume116en_US
mit.journal.issue49en_US
mit.licensePUBLISHER_POLICY


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