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dc.contributor.authorChertok, Beata
dc.contributor.authorWebber, Matthew J.
dc.contributor.authorSucci, Marc D.
dc.contributor.authorLanger, Robert S
dc.date.accessioned2020-04-24T19:42:59Z
dc.date.available2020-04-24T19:42:59Z
dc.date.issued2013-08
dc.identifier.issn1543-8392
dc.identifier.issn1543-8384
dc.identifier.urihttps://hdl.handle.net/1721.1/124872
dc.description.abstractEarly science fiction envisioned the future of drug delivery as targeted micrometer-scale submarines and "cyborg" body parts. Here we describe the progression of the field toward technologies that are now beginning to capture aspects of this early vision. Specifically, we focus on the two most prominent types of systems in drug delivery: the intravascular micro/nano drug carriers for delivery to the site of pathology and drug-loaded implantable devices that facilitate release with the predefined kinetics or in response to a specific cue. We discuss the unmet clinical needs that inspire these designs, the physiological factors that pose difficult challenges for their realization, and viable technologies that promise robust solutions. We also offer a perspective on where drug delivery may be in the next 50 years based on expected advances in material engineering and in the context of future diagnostics. Keywords: drug delivery; drug carriers; nanotechnology; controlled release implants; physiological barriers; pharmacokinetics; translational medicineen_US
dc.description.sponsorshipNational Institute of Biomedical Imaging and Bioengineering (U.S.) (Grant 1F32EB015835-01)en_US
dc.language.isoen
dc.publisherAmerican Chemical Society (ACS)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1021/MP4003283en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourcePMCen_US
dc.titleDrug Delivery Interfaces in the 21st Century: From Science Fiction Ideas to Viable Technologiesen_US
dc.typeArticleen_US
dc.identifier.citationChertok, Beata, et al. “Drug Delivery Interfaces in the 21st Century: From Science Fiction Ideas to Viable Technologies.” Molecular Pharmaceutics 10, 10 (October 2013): 3531–43.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.relation.journalMolecular Pharmaceuticsen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2019-09-04T18:44:11Z
dspace.date.submission2019-09-04T18:44:13Z
mit.journal.volume10en_US
mit.journal.issue10en_US
mit.metadata.statusComplete


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