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Profiling of Target Molecules for Immunotherapy in Mesenchymal Tumors

Author(s)
Tonegawa, Susumu
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Creative Commons Attribution NonCommercial License 4.0 https://creativecommons.org/licenses/by-nc/4.0/
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Abstract
The use of anti-human signal molecules monoclonal antibod-ies (mAbs) for malignant tumors therapy has achieved consid-erable success in recent years. Antibody drug conjugates are powerful new clinical treatment options for lymphomas and solid tumors, and immunomodulatory antibodies have also re-cently achieved remarkable clinical success. The development of therapeutic antibodies requires a deep understanding of ma-lignant tumor serology, protein-engineering techniques, mech-anisms of action and resistance, and the interplay between the immune system and tumorigenesis. This review outlines the fundamental strategies, which are required to establish anti-body therapies for patients with mesenchymal tumors through iterative approaches to target and antibody selection, extend-ing from preclinical studies to human trials.
Date issued
2019
URI
https://hdl.handle.net/1721.1/124938
Department
Picower Institute for Learning and Memory
Journal
Journal of clinical medicine and research
Publisher
Elmer Press, Inc.
Citation
Hayashi,Takuma et al. “Profiling of Target Molecules for Immunotherapy in Mesenchymal Tumors.” Journal of clinical medicine and research 11 (2019): 609-613 © 2019 The Author(s)
Version: Final published version
ISSN
1918-3003
1918-3011

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