WNT Signaling in Cancer Immunosurveillance
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Deregulated WNT signaling has been shown to favor malignant transformation, tumor progression, and resistance to conventional cancer therapy in a variety of preclinical and clinical settings. Accumulating evidence suggests that aberrant WNT signaling may also subvert cancer immunosurveillance, hence promoting immunoevasion and resistance to multiple immunotherapeutics, including immune checkpoint blockers. Here, we discuss the molecular and cellular mechanisms through which WNT signaling influences cancer immunosurveillance and present potential therapeutic avenues to harness currently available WNT modulators for cancer immunotherapy.
DepartmentMassachusetts Institute of Technology. Department of Biology; Koch Institute for Integrative Cancer Research at MIT
Trends in Cell Biology
Galluzzi, Lorenzo et al. “WNT Signaling in Cancer Immunosurveillance.” Trends in Cell Biology 29 (2019): 44-65 © 2019 The Author(s)
Author's final manuscript