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dc.contributor.authorFudenberg, Geoffrey
dc.contributor.authorAbdennur, Nezar Alexander
dc.contributor.authorImakaev, Maxim
dc.contributor.authorGoloborodko, Anton
dc.contributor.authorMirny, Leonid A.
dc.date.accessioned2020-05-06T14:42:49Z
dc.date.available2020-05-06T14:42:49Z
dc.date.issued2017
dc.identifier.issn0091-7451
dc.identifier.issn1943-4456
dc.identifier.urihttps://hdl.handle.net/1721.1/125044
dc.description.abstractChromosome organization poses a remarkable physical problem with many biological consequences: How can molecular interactions between proteins at the nanometer scale organize micron-long chromatinized DNA molecules, insulating or facilitating interactions between specific genomic elements? The mechanism of active loop extrusion holds great promise for explaining interphase and mitotic chromosome folding, yet remains difficult to assay directly. We discuss predictions from our polymer models of loop extrusion with barrier elements and review recent experimental studies that provide strong support for loop extrusion, focusing on perturbations to CTCF and cohesin assayed via Hi-C in interphase. Finally, we discuss a likely molecular mechanism of loop extrusion by structural maintenance of chromosomes complexes. Keywords: genetics; biochemistry; molecular biology.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant GM114190)en_US
dc.description.sponsorshipNational Science Foundation. Physics of Living Systems (Grant 15049420)en_US
dc.description.sponsorshipNational Science Foundation. Center for 3D Structure and Physics of the Genome (Grant DK107980)en_US
dc.language.isoen
dc.publisherCold Spring Harbor Laboratoryen_US
dc.relation.isversionofhttp://dx.doi.org/10.1101/sqb.2017.82.034710en_US
dc.rightsCreative Commons Attribution 4.0 International licenseen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.sourceCold Spring Harbor Laboratory Pressen_US
dc.titleEmerging Evidence of Chromosome Folding by Loop Extrusionen_US
dc.typeArticleen_US
dc.identifier.citationFudenberg, Geoffrey et al. "Emerging Evidence of Chromosome Folding by Loop Extrusion." Cold Spring Harbor Symposia on Quantitative Biology 82 (2017): 45-54 ©2017 The Author(s)en_US
dc.contributor.departmentMassachusetts Institute of Technology. Computational and Systems Biology Programen_US
dc.contributor.departmentMassachusetts Institute of Technology. Institute for Medical Engineering and Scienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Physicsen_US
dc.relation.journalCold Spring Harbor Symposia on Quantitative Biologyen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2019-10-09T16:48:48Z
dspace.date.submission2019-10-09T16:48:49Z
mit.journal.volume82en_US


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