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dc.contributor.authorRhoades, Jeffrey L.
dc.contributor.authorNwabudike, Ijeoma
dc.contributor.authorYu, Stephanie K.
dc.contributor.authorMcLachlan, Ian G.
dc.contributor.authorMadan, Gurrein K.
dc.contributor.authorAbebe, Eden
dc.contributor.authorPowers, Joshua R.
dc.contributor.authorFlavell, Steven Willem
dc.date.accessioned2020-05-26T12:42:25Z
dc.date.available2020-05-26T12:42:25Z
dc.date.issued2019-01
dc.identifier.issn0092-8674
dc.identifier.urihttps://hdl.handle.net/1721.1/125439
dc.description.abstractAnimals must respond to the ingestion of food by generating adaptive behaviors, but the role of gut-brain signaling in behavioral regulation is poorly understood. Here, we identify conserved ion channels in an enteric serotonergic neuron that mediate its responses to food ingestion and decipher how these responses drive changes in foraging behavior. We show that the C. elegans serotonergic neuron NSM acts as an enteric sensory neuron that acutely detects food ingestion. We identify the novel and conserved acid-sensing ion channels (ASICs) DEL-7 and DEL-3 as NSM-enriched channels required for feeding-dependent NSM activity, which in turn drives slow locomotion while animals feed. Point mutations that alter the DEL-7 channel change NSM dynamics and associated behavioral dynamics of the organism. This study provides causal links between food ingestion, molecular and physiological properties of an enteric serotonergic neuron, and adaptive feeding behaviors, yielding a new view of how enteric neurons control behavior.en_US
dc.description.sponsorshipUniversity of Minnesota. Caenorhabditis Genetics Center (Grant P40 OD010440)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant R01NS104892)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant R01NS076558)en_US
dc.description.sponsorshipNational Science Foundation (U.S.) (Grant IOS 1353845)en_US
dc.language.isoen
dc.publisherElsevier BVen_US
dc.relation.isversionofhttps://dx.doi.org/10.1016/J.CELL.2018.11.023en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourcePMCen_US
dc.titleASICs Mediate Food Responses in an Enteric Serotonergic Neuron that Controls Foraging Behaviorsen_US
dc.typeArticleen_US
dc.identifier.citationRhoades, Jeffrey L. et al. “ASICs Mediate Food Responses in an Enteric Serotonergic Neuron that Controls Foraging Behaviors.” Cell 176 (2019): 85-97.e14 © 2019 The Author(s)en_US
dc.contributor.departmentPicower Institute for Learning and Memoryen_US
dc.relation.journalCellen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2020-01-21T16:26:01Z
dspace.date.submission2020-01-21T16:26:03Z
mit.journal.volume176en_US
mit.journal.issue1-2en_US
mit.metadata.statusComplete


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