Monotopic Membrane Proteins Join the Fold
Author(s)Entova, Sonya.; Imperiali, Barbara
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Monotopic membrane proteins, classified by topology, are proteins that embed into a single face of the membrane. These proteins are generally underrepresented in the Protein Data Bank (PDB), but the past decade of research has revealed new examples that allow the description of generalizable features. This Opinion article summarizes shared characteristics including oligomerization states, modes of membrane association, mechanisms of interaction with hydrophobic or amphiphilic substrates, and homology to soluble folds. We also discuss how associations of monotopic enzymes in pathways can be used to promote substrate specificity and product composition. These examples highlight the challenges in structure determination specific to this class of proteins, but also the promise of new understanding from future study of these proteins that reside at the interface.
DepartmentMassachusetts Institute of Technology. Department of Biology; Massachusetts Institute of Technology. Department of Chemistry
Trends in biochemical sciences
Allen, Karen N. et al. “Monotopic Membrane Proteins Join the Fold.” Trends in biochemical sciences 44 (2019): 7-20 © 2019 The Author(s)
Author's final manuscript