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dc.contributor.authorRoberts, Erin G.
dc.contributor.authorRim, Nae‐Gyune
dc.contributor.authorHuang, Wenwen
dc.contributor.authorTarakanova, Anna
dc.contributor.authorYeo, Jingjie
dc.contributor.authorBuehler, Markus J
dc.contributor.authorKaplan, David L.
dc.contributor.authorWong, Joyce Y.
dc.date.accessioned2020-05-27T17:56:50Z
dc.date.available2020-05-27T17:56:50Z
dc.date.issued2018-11
dc.date.submitted2018-09
dc.identifier.issn1616-5187
dc.identifier.issn1616-5195
dc.identifier.urihttps://hdl.handle.net/1721.1/125511
dc.description.abstractSilk-elastin-like-protein polymers (SELPs) are genetically engineered recombinant protein sequences consisting of repeating units of silk-like and elastin-like blocks. By combining these entities, it is shown that both the characteristic strength of silk and the temperature-dependent responsiveness of elastin can be leveraged to create an enhanced stimuli-responsive material. It is hypothesized that SELP behavior can be influenced by varying the silk-to-elastin ratio. If the responsiveness of the material at different ratios is significantly different, this would allow for the design of materials with specific temperature-based swelling and mechanical properties. This study demonstrates that SELP fiber properties can be controlled via a temperature transition dependent on the ratio of silk-to-elastin in the material. SELP fibers are experimentally wet spun from polymers with different ratios of silk-to-elastin and conditioned in either a below or above transition temperature (T t) water bath prior to characterization. The fibers with higher elastin content showed more stimuli-responsive behavior compared to the fibers with lower elastin content in the hot (57–60 °C) versus cold (4–7 °C) environment, both computationally and experimentally. This work builds a foundation for developing SELP materials with well-characterized mechanical properties and responsive features.en_US
dc.language.isoen
dc.publisherWileyen_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/mabi.201800265en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleFabrication and Characterization of Recombinant Silk‐Elastin‐Like‐Protein (SELP) Fiberen_US
dc.typeArticleen_US
dc.identifier.citationRoberts, Erin G. et al. "Fabrication and Characterization of Recombinant Silk‐Elastin‐Like‐Protein (SELP) Fiber." Macromolecular Bioscience 18, 12 (November 2018): e1800265 © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheimen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Civil and Environmental Engineeringen_US
dc.relation.journalMacromolecular Bioscienceen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2020-05-15T19:23:39Z
dspace.date.submission2020-05-15T19:23:42Z
mit.journal.volume18en_US
mit.journal.issue12en_US
mit.licenseOPEN_ACCESS_POLICY


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