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Proteomic and metabolomic correlates of healthy dietary patterns: the Framingham Heart Study

Author(s)
Walker, Maura E.; Song, Rebecca J.; Xu, Xiang; Gerszten, Robert E.; Ngo, Debby; Clish, Clary; Corlin, Laura; Ma, Jiantao; Xanthakis, Vanessa; Jacques, Paul F.; Vasan, Ramachandran S.; ... Show more Show less
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Abstract
Data on proteomic and metabolomic signatures of healthy dietary patterns are limited. We evaluated the cross-sectional association of serum proteomic and metabolomic markers with three dietary patterns: the Alternative Healthy Eating Index (AHEI), the Dietary Approaches to Stop Hypertension (DASH) diet; and a Mediterranean-style (MDS) diet. We examined participants from the Framingham Offspring Study (mean age; 55 years; 52% women) who had complete proteomic (n = 1713) and metabolomic (n = 2284) data; using food frequency questionnaires to derive dietary pattern indices. Proteins and metabolites were quantified using the SomaScan platform and liquid chromatography/tandem mass spectrometry; respectively. We used multivariable-adjusted linear regression models to relate each dietary pattern index (independent variables) to each proteomic and metabolomic marker (dependent variables). Of the 1373 proteins; 103 were associated with at least one dietary pattern (48 with AHEI; 83 with DASH; and 8 with MDS; all false discovery rate [FDR] ≤ 0.05). We identified unique associations between dietary patterns and proteins (17 with AHEI; 52 with DASH; and 3 with MDS; all FDR ≤ 0.05). Significant proteins enriched biological pathways involved in cellular metabolism/proliferation and immune response/inflammation. Of the 216 metabolites; 65 were associated with at least one dietary pattern (38 with AHEI; 43 with DASH; and 50 with MDS; all FDR ≤ 0.05). All three dietary patterns were associated with a common signature of 24 metabolites (63% lipids). Proteins and metabolites associated with dietary patterns may help characterize intermediate phenotypes that provide insights into the molecular mechanisms mediating diet-related disease. Our findings warrant replication in independent populations. Keywords: dietary patterns; diet quality; proteomic; metabolomic; biomarker
Date issued
2020-05
URI
https://hdl.handle.net/1721.1/125742
Department
Broad Institute of MIT and Harvard
Journal
Nutrients
Publisher
Multidisciplinary Digital Publishing Institute
Citation
Walker, Maura E., et al., "Proteomic and metabolomic correlates of healthy dietary patterns: the Framingham Heart Study." Nutrients 12, 5 (May 2020): no. 1476 doi 10.3390/nu12051476 ©2020 Author(s)
Version: Final published version
ISSN
2072-6643

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