dc.contributor.author | Alvaradejo, Gabriela Gil | |
dc.contributor.author | Nguyen, Hung VanThanh | |
dc.contributor.author | Harvey, Peter | |
dc.contributor.author | Gallagher, Nolan | |
dc.contributor.author | Le, Dao | |
dc.contributor.author | Ottaviani, M. Francesca | |
dc.contributor.author | Jasanoff, Alan Pradip | |
dc.contributor.author | Delaittre, Guillaume | |
dc.contributor.author | Johnson, Jeremiah A. | |
dc.date.accessioned | 2020-06-17T14:00:43Z | |
dc.date.available | 2020-06-17T14:00:43Z | |
dc.date.issued | 2019-04 | |
dc.date.submitted | 2019-01 | |
dc.identifier.issn | 2161-1653 | |
dc.identifier.issn | 2161-1653 | |
dc.identifier.uri | https://hdl.handle.net/1721.1/125832 | |
dc.description.abstract | The synthesis of functional poly(2-alkyl-2-oxazoline) (PAOx) copolymers with complex nanoarchitectures using a graft-through ring-opening metathesis polymerization (ROMP) approach is described. First, well-defined norbornene-terminated poly(2-ethyl-2-oxazoline) (PEtOx) macromonomers (MM) were prepared by cationic ring-opening polymerization. ROMP of these MMs produced bottlebrush copolymers with PEtOx side chains. In addition, PEtOx-based branched MMs bearing a terminal alkyne group were prepared and conjugated to an azide-containing bis-spirocyclohexyl nitroxide via Cu-catalyzed azide-alkyne cycloaddition (CuAAC). ROMP of this branched MM, followed by in situ cross-linking, provided PEtOx-based brush-arm star polymers (BASPs) with nitroxide radicals localized at the core-shell interface. These PEtOx-based nitroxide-containing BASPs displayed relaxivity values on par with state-of-the-art polyethylene glycol (PEG)-based nitroxide materials, making them promising as organic radical contrast agents for metal-free magnetic resonance imaging (MRI). | en_US |
dc.language.iso | en | |
dc.publisher | American Chemical Society (ACS) | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1021/acsmacrolett.9b00016 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | PMC | en_US |
dc.title | Polyoxazoline-Based Bottlebrush and Brush-Arm Star Polymers via ROMP: Syntheses and Applications as Organic Radical Contrast Agents | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Alvaradejo, Gabriela Gil et al. "Polyoxazoline-Based Bottlebrush and Brush-Arm Star Polymers via ROMP: Syntheses and Applications as Organic Radical Contrast Agents." ACS Macro Letters 8, 4 (April 2019): 473–478 © 2019 American Chemical Society | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Nuclear Science and Engineering | en_US |
dc.relation.journal | ACS Macro Letters | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dc.date.updated | 2019-12-23T14:40:09Z | |
dspace.date.submission | 2019-12-23T14:40:12Z | |
mit.journal.volume | 8 | en_US |
mit.journal.issue | 4 | en_US |
mit.license | PUBLISHER_POLICY | |
mit.metadata.status | Complete | |