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Determinants of nutrient limitation in cancer

Author(s)
Sullivan, Mark Robert; Vander Heiden, Matthew G.
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Abstract
Proliferation requires that cells accumulate sufficient biomass to grow and divide. Cancer cells within tumors must acquire a variety of nutrients, and tumor growth slows or stops if necessary metabolites are not obtained in sufficient quantities. Importantly, the metabolic demands of cancer cells can be different from those of untransformed cells, and nutrient accessibility in tumors is different than in many normal tissues. Thus, cancer cell survival and proliferation may be limited by different metabolic factors than those that are necessary to maintain noncancerous cells. Understanding the variables that dictate which nutrients are critical to sustain tumor growth may identify vulnerabilities that could be used to treat cancer. This review examines the various cell-autonomous, local, and systemic factors that determine which nutrients are limiting for tumor growth.
Date issued
2019-05
URI
https://hdl.handle.net/1721.1/125935
Department
David H. Koch Institute for Integrative Cancer Research at MIT
Journal
Critical Reviews in Biochemistry and Molecular Biology
Publisher
Informa UK Limited
Citation
Sullivan, Mark R. and Matthew G. Vander Heiden. "Determinants of nutrient limitation in cancer." Critical Reviews in Biochemistry and Molecular Biology 54, 3 (May 2019): 193-207 © 2019 Informa UK Limited
Version: Author's final manuscript
ISSN
1040-9238
1549-7798

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