dc.contributor.author | Windmann, Victoria | |
dc.contributor.author | Spies, Claudia | |
dc.contributor.author | Brown, Emery Neal | |
dc.contributor.author | Kishnan, Devika | |
dc.contributor.author | Lichtner, Gregor | |
dc.contributor.author | Koch, Susanne | |
dc.date.accessioned | 2020-06-23T18:04:40Z | |
dc.date.available | 2020-06-23T18:04:40Z | |
dc.date.issued | 2019-09 | |
dc.identifier.issn | 1388-2457 | |
dc.identifier.uri | https://hdl.handle.net/1721.1/125942 | |
dc.description.abstract | Objective: To investigate the influence of midazolam premedication on the EEG-spectrum before and during general anesthesia in elderly patients.
Methods: Patients aged ≥65 years, undergoing elective surgery were included in this prospective observational study. A continuous pre- and intraoperative frontal EEG was recorded in patients who received premedication with midazolam (Mid, n = 15) and patients who did not (noMid, n = 30). Absolute power within the delta (0.5–4 Hz), theta (4–8 Hz), alpha (8–12 Hz), and beta (12–25 Hz) frequency-bands was analyzed in EEG-sections before (pre-induction), and after induction of anesthesia with propofol (post-induction), as well as during general anesthesia with either propofol or volatile-anesthetics (intra-operative).
Results: Pre-induction, α-power of Mid patients was lower compared with noMid-patients (α-power: Mid: −10.75 dB vs. noMid: −9.20 dB; p = 0.036). After induction of anesthesia Mid-patients displayed a stronger increase of frontal α-power resulting in higher absolute α-power at post-induction state, (α-power: Mid −3.56 dB vs. noMid: −6.69 dB; p = 0.004), which remained higher intraoperatively (α-power: Mid: −2.12 dB vs. noMid: −6.10 dB; p = 0.024).
Conclusion: Midazolam premedication alters the intraoperative EEG-spectrum in elderly patients.
Significance: This finding provides further evidence for the role of GABAergic activation in the induction of elevated, frontal α-power during general anesthesia. | en_US |
dc.publisher | Elsevier BV | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1016/j.clinph.2019.05.035 | en_US |
dc.rights | Creative Commons Attribution-NonCommercial-NoDerivs License | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
dc.source | Prof. Brown via Courtney Crummett | en_US |
dc.title | Influence of midazolam premedication on intraoperative EEG signatures in elderly patients | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Windmann, Victoria et al. "Influence of midazolam premedication on intraoperative EEG signatures in elderly patients." Clinical Neurophysiology 130, 9 (September 2019): 1673-1681 © 2019 International Federation of Clinical Neurophysiology | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Institute for Medical Engineering & Science | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Institute for Data, Systems, and Society | en_US |
dc.contributor.department | Picower Institute for Learning and Memory | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences | en_US |
dc.contributor.department | Harvard University--MIT Division of Health Sciences and Technology | en_US |
dc.relation.journal | Clinical Neurophysiology | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.date.submission | 2019-12-13T12:49:36Z | |
mit.journal.volume | 130 | en_US |
mit.journal.issue | 9 | en_US |
mit.metadata.status | Complete | |