MIT Libraries logoDSpace@MIT

MIT
View Item 
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

IFN-γ-independent immune markers of Mycobacterium tuberculosis exposure

Author(s)
Lu, Lenette L.; Smith, Malisa T.; Yu, Krystle K. Q.; Luedemann, Corinne; Suscovich, Todd J.; Grace, Patricia S.; Cain, Adam; Yu, Wen-Han; McKitrick, Tanya R.; Lauffenburger, Douglas A; Cummings, Richard D.; Mayanja-Kizza, Harriet; Hawn, Thomas R.; Boom, W. Henry; Stein, Catherine M.; Fortune, Sarah M.; Seshadri, Chetan; Alter, Galit; ... Show more Show less
Thumbnail
DownloadPublished version (8.803Mb)
Publisher with Creative Commons License

Publisher with Creative Commons License

Creative Commons Attribution

Terms of use
Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/
Metadata
Show full item record
Abstract
Exposure to Mycobacterium tuberculosis (Mtb) results in heterogeneous clinical outcomes including primary progressive tuberculosis and latent Mtb infection (LTBI). Mtb infection is identified using the tuberculin skin test and interferon-γ (IFN-γ) release assay IGRA, and a positive result may prompt chemoprophylaxis to prevent progression to tuberculosis. In the present study, we report on a cohort of Ugandan individuals who were household contacts of patients with TB. These individuals were highly exposed to Mtb but tested negative disease by IFN-γ release assay and tuberculin skin test, ‘resisting’ development of classic LTBI. We show that ‘resisters’ possess IgM, class-switched IgG antibody responses and non-IFN-γ T cell responses to the Mtb-specific proteins ESAT6 and CFP10, immunologic evidence of exposure to Mtb. Compared to subjects with classic LTBI, ‘resisters’ display enhanced antibody avidity and distinct Mtb-specific IgG Fc profiles. These data reveal a distinctive adaptive immune profile among Mtb-exposed subjects, supporting an expanded definition of the host response to Mtb exposure, with implications for public health and the design of clinical trials.
Date issued
2019-05
URI
https://hdl.handle.net/1721.1/125979
Department
Massachusetts Institute of Technology. Department of Biological Engineering
Journal
Nature Medicine
Publisher
Springer Science and Business Media LLC
Citation
Lu, Lenette L. et al. "IFN-γ-independent immune markers of Mycobacterium tuberculosis exposure." Nature Medicine 25, 6 (May 2019): 977–987 © 2019 The Author(s)
Version: Final published version
ISSN
1078-8956
1546-170X

Collections
  • MIT Open Access Articles

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

Login

Statistics

OA StatisticsStatistics by CountryStatistics by Department
MIT Libraries
PrivacyPermissionsAccessibilityContact us
MIT
Content created by the MIT Libraries, CC BY-NC unless otherwise noted. Notify us about copyright concerns.