Metazoan MicroRNAs
Name
nihms948672.pdf
Description
Accepted version
Size
1.21 MB
Format
Adobe PDF
Checksum (MD5)
b904e4bdac707d100ded78b2f9e8c293
Author(s)
Bartel, David
Date Issued
March 2018
Journal
Cell
Publisher
Elsevier BV
Citation
David P. Bartel. "Metazoan MicroRNAs." Cell 173, 1 (March 2018): P20-51 © 2018 Elsevier Inc
Version
Author's final manuscript
Abstract
MicroRNAs (miRNAs) are ∼22 nt RNAs that direct posttranscriptional repression of mRNA targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs help sculpt the expression of most mRNAs. This article reviews advances in our understanding of the defining features of metazoan miRNAs and their biogenesis, genomics, and evolution. It then reviews how metazoan miRNAs are regulated, how they recognize and cause repression of their targets, and the biological functions of this repression, with a compilation of knockout phenotypes that shows that important biological functions have been identified for most of the broadly conserved miRNAs of mammals. MicroRNAs are pervasive sculptors of gene expression in animals. This review describes these small regulatory RNAs and their biogenesis, regulation, target recognition, mechanism of action, evolution, and biological functions.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.cell.2018.03.006
