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dc.contributor.authorPender, Corinne Lenore
dc.contributor.authorHorvitz, Howard Robert
dc.date.accessioned2020-07-07T19:36:28Z
dc.date.available2020-07-07T19:36:28Z
dc.date.issued2018-07
dc.date.submitted2018-03
dc.identifier.issn2050-084X
dc.identifier.urihttps://hdl.handle.net/1721.1/126077
dc.description.abstractThe HIF (hypoxia-inducible factor) transcription factor is the master regulator of the metazoan response to chronic hypoxia. In addition to promoting adaptations to low oxygen, HIF drives cytoprotective mechanisms in response to stresses and modulates neural circuit function. How most HIF targets act in the control of the diverse aspects of HIF-regulated biology remains unknown. We discovered that a HIF target, the C. elegans gene cyp-36A1, is required for numerous HIF-dependent processes, including modulation of gene expression, stress resistance, and behavior. cyp-36A1encodes a cytochrome P450 enzyme that we show controls expression of more than a third of HIF-induced genes. CYP-36A1 acts cell non-autonomously by regulating the activity of the nuclear hormone receptor NHR-46, suggesting that CYP-36A1 functions as a biosynthetic enzyme for a hormone ligand of this receptor. We propose that regulation of HIF effectors through activation of cytochrome P450 enzyme/nuclear receptor signaling pathways could similarly occur in humans.en_US
dc.description.sponsorshipNational Institutes of Health (Grant GM024663)en_US
dc.description.sponsorshipNational Institutes of Health (Grant T32GM007287)en_US
dc.language.isoen
dc.publishereLife Sciences Publications, Ltden_US
dc.relation.isversionofhttp://dx.doi.org/10.7554/elife.36828en_US
dc.rightsCreative Commons Attribution 4.0 International licenseen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.sourceeLifeen_US
dc.titleHypoxia-inducible factor cell non-autonomously regulates C. elegans stress responses and behavior via a nuclear receptoren_US
dc.typeArticleen_US
dc.identifier.citationPender, Corrine L. and H. Robert Horvitz. "Hypoxia-inducible factor cell non-autonomously regulates C. elegans stress responses and behavior via a nuclear receptor." eLife 7 (July 2018): e36828 © 2018 Pender and Horvitzen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentMcGovern Institute for Brain Research at MITen_US
dc.contributor.departmentDavid H. Koch Institute for Integrative Cancer Research at MITen_US
dc.relation.journaleLIfeen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2019-12-05T18:26:02Z
dspace.date.submission2019-12-05T18:26:04Z
mit.journal.volume7en_US


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