Ni-catalyzed electrochemical decarboxylative C-C couplings in batch and continuous flow
Author(s)Li, Hui; Breen, Christopher P.; Seo, Hyowon; Jamison, Timothy F; Fang, Yuan-Qing; Bio, Matthew M.; ... Show more Show less
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An electrochemically driven, nickel-catalyzed reductive coupling of N-hydroxyphthalimide esters with aryl halides is reported. The reaction proceeds under mild conditions in a divided electrochemical cell and employs a tertiary amine as the reductant. This decarboxylative C(sp[superscript 3])-C(sp[superscript 2]) bond-forming transformation exhibits excellent substrate generality and functional group compatibility. An operationally simple continuous-flow version of this transformation using a commercial electrochemical flow reactor represents a robust and scalable synthesis of value added coupling process.
DepartmentMassachusetts Institute of Technology. Department of Chemistry; Massachusetts Institute of Technology. Department of Chemical Engineering
American Chemical Society (ACS)
Li, Hui, et al. "Ni-catalyzed electrochemical decarboxylative C-C couplings in batch and continuous flow." Organic Letters 20, 5 (Mar. 2018): p. 1338-41 doi 10.1021/ACS.ORGLETT.8B00070 ©2018 Author(s)
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