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The role of engram cells in the systems consolidation of memory

Author(s)
Tonegawa, Susumu; Morrissey, Mark; Kitamura, Takashi
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Abstract
What happens to memories as days, weeks and years go by has long been a fundamental question in neuroscience and psychology. For decades, researchers have attempted to identify the brain regions in which memory is formed and to follow its changes across time. The theory of systems consolidation of memory (SCM) suggests that changes in circuitry and brain networks are required for the maintenance of a memory with time. Various mechanisms by which such changes may take place have been hypothesized. Recently, several studies have provided insight into the brain networks driving SCM through the characterization of memory engram cells, their biochemical and physiological changes and the circuits in which they operate. In this Review, we place these findings in the context of the field and describe how they have led to a revamped understanding of SCM in the brain.
Date issued
2018-07
URI
https://hdl.handle.net/1721.1/126264
Department
RIKEN-MIT Center for Neural Circuit Genetics; Picower Institute for Learning and Memory; Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences; Massachusetts Institute of Technology. Department of Biology
Journal
Nature Reviews Neuroscience
Publisher
Springer Science and Business Media LLC
Citation
Tonegawa, Susumu et al. "The role of engram cells in the systems consolidation of memory." Nature Reviews Neuroscience 19, 8 (July 2018): 485–498 © 2018 Macmillan Publishers Ltd., part of Springer Nature
Version: Author's final manuscript
ISSN
1471-003X
1471-0048

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