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dc.contributor.authorOr, Chris
dc.contributor.authorHeier, Jeffrey S
dc.contributor.authorBoyer, David
dc.contributor.authorBrown, David
dc.contributor.authorShah, Sumit
dc.contributor.authorAlibhai, Agha Y
dc.contributor.authorFujimoto, James G
dc.contributor.authorWaheed, Nadia
dc.date.accessioned2020-07-23T20:14:03Z
dc.date.available2020-07-23T20:14:03Z
dc.date.issued2019-08-20
dc.date.submitted2019-05
dc.identifier.issn2056-9920
dc.identifier.urihttps://hdl.handle.net/1721.1/126363
dc.description.abstractBACKGROUND: To investigate whether neovascularization may arise and be detectable in drusen, as reported in histopathologic studies, by OCTA prior to developing exudation and to assess its prevalence in a cohort of patients with intermediate AMD. METHODS: Retrospective cross-sectional study of 128 patients with intermediate AMD recruited as part of a separate ongoing clinical trial conducted at multiple large tertiary referral retina clinics. One hundred and twenty-eight consecutive patients with exudative AMD in one eye and intermediate non-exudative AMD in the fellow eye were enrolled and analyzed between September 2015 and March 2017. RESULTS: SD-OCTA identified vascularization within drusen in 7 of 128 eyes, for a prevalence of 5.5%. A total of 12 instances of vascularized drusen were noted. Out of the 12 vascularized drusen noted, 7 were located in the parafoveal region or subfoveal region and 5 was in the extrafoveal region. 9 of 12 instances of vascularized drusen exhibited a uniform sub-RPE hyperreflectivity, whilst 3 of 12 exhibited more heterogenous reflectivity. In all 12 instances, FA images failed to identify the neovascular nature of vascularized drusen. CONCLUSIONS: Our results demonstrate the utility of SD-OCTA for the diagnosis of vascularized drusen in patients with intermediate non-exudative AMD. Longitudinal studies are needed to delineate the evolution and conversion risk of these lesions over time, which can be of substantial clinical relevance.en_US
dc.publisherBioMed Centralen_US
dc.relation.isversionof10.1186/s40942-019-0187-6en_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.sourceBioMed Centralen_US
dc.titleVascularized drusen: a cross-sectional studyen_US
dc.typeArticleen_US
dc.identifier.citationOr, Chris et al. "Vascularized drusen: a cross-sectional study." International Journal of Retina and Vitreous 5 (August 2019): 36 ©2019 Author(s)en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Scienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Research Laboratory of Electronicsen_US
dc.relation.journalInternational Journal of Retina and Vitreousen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2020-06-26T11:13:08Z
dc.language.rfc3066en
dc.rights.holderThe Author(s)
dspace.date.submission2020-06-26T11:13:08Z
mit.journal.volume5en_US
mit.licensePUBLISHER_CC


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