A microcomposite hydrogel for repeated on-demand ultrasound-triggered drug delivery
Author(s)Epstein-Barash, Hila; Orbey, Gizem; Polat, Baris E.; Ewoldt, Randy H.; Feshitan, Jameel; Langer, Robert S; Borden, Mark A.; Kohane, Daniel S; ... Show more Show less
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Here we develop an injectable composite system based for repeated ultrasound-triggered on-demand drug delivery. An in situ-cross-linking hydrogel maintains model drug (dye)-containing liposomes in close proximity to gas-filled microbubbles that serve to enhance release events induced by ultrasound application. Dye release is tunable by varying the proportions of the liposomal and microbubble components, as well as the duration and intensity of the ultrasound pulses in vitro. Dye is minimal at baseline. The composite shows minimal cytotoxicity in vitro, and benign tissue reaction after subcutaneous injection in rats. Ultrasound application also triggers drug release for two weeks after injection in vivo. ©2010 Elsevier Ltd.
DepartmentHarvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Mechanical Engineering
Epstein-Barash, Hila et al., "A microcomposite hydrogel for repeated on-demand ultrasound-triggered drug delivery." Biomaterials 31,19 (July 2010): p. 5208-17 doi. 10.1016/j.biomaterials.2010.03.008 ©2010 Authors
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