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dc.contributor.authorYuan, Rodger
dc.contributor.authorLee, Jaemyon
dc.contributor.authorSu, Hao-Wei
dc.contributor.authorLevy, Etgar Claude
dc.contributor.authorKhudiyev, Tural
dc.contributor.authorVoldman, Joel
dc.contributor.authorFink, Yoel
dc.date.accessioned2020-07-28T22:29:40Z
dc.date.available2020-07-28T22:29:40Z
dc.date.issued2018-10
dc.date.submitted2018-06
dc.identifier.issn1091-6490
dc.identifier.urihttps://hdl.handle.net/1721.1/126427
dc.description.abstractTraditional fabrication techniques for microfluidic devices utilize a planar chip format that possesses limited control over the geometry of and materials placement around microchannel cross-sections. This imposes restrictions on the design of flow fields and external forces (electric, magnetic, piezoelectric, etc.) that can be imposed onto fluids and particles. Here we report a method of fabricating microfluidic channels with complex cross-sections. A scaled-up version of a microchannel is dimensionally reduced through a thermal drawing process, enabling the fabrication of meters-long microfluidic fibers with nonrectangular cross-sectional shapes, such as crosses, five-pointed stars, and crescents. In addition, by codrawing compatible materials, conductive domains can be integrated at arbitrary locations along channel walls. We validate this technology by studying unexplored regimes in hydrodynamic flow and by designing a high-throughput cell separation device. By enabling these degrees of freedom in microfluidic device design, fiber microfluidics provides a method to create microchannel designs that are inaccessible using planar techniques. ©2018en_US
dc.description.sponsorshipNSF - Center for Materials Science and Engineering (DMR-0819762)en_US
dc.description.sponsorshipNSF - Center for Materials Science and Engineering (DMR-1419807)en_US
dc.description.sponsorshipUS Army Research Lab. & the US Army Research Office through the Institute for Soldier Nanotechnologies (Contract W911NF-13-D-0001)en_US
dc.description.sponsorshipNIH (Contract 1R21EB022729).en_US
dc.description.sponsorshipDefense Advanced Research Projects Agency (Contract N66001-11-1-4182)en_US
dc.description.sponsorshipNIH (Contract (1U24AI118656)en_US
dc.description.sponsorshipNIH (Contract 1R21EB022729)en_US
dc.language.isoen
dc.publisherProceedings of the National Academy of Sciencesen_US
dc.relation.isversionofhttps://dx.doi.org/10.1073/PNAS.1809459115en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourcePNASen_US
dc.titleMicrofluidics in structured multimaterial fibersen_US
dc.typeArticleen_US
dc.identifier.citationYuan, Rodger et al., "Microfluidics in structured multimaterial fibers." Proceedings of the National Academy of Sciences of the United States of America 115, 46 (November 2018): p. E10830-E10838 doi. 10.1073/pnas.1809459115 ©2018 Authorsen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Materials Science and Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Scienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Research Laboratory of Electronicsen_US
dc.contributor.departmentMassachusetts Institute of Technology. Microsystems Technology Laboratoriesen_US
dc.relation.journalProceedings of the National Academy of Sciences of the United States of Americaen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2019-09-16T14:03:18Z
dspace.date.submission2019-09-16T14:03:21Z
mit.journal.volume115en_US
mit.journal.issue46en_US


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