| dc.contributor.author | Zhong, Cheng | |
| dc.contributor.author | Ramek, Alexander | |
| dc.contributor.author | Koehler, Angela Nicole | |
| dc.date.accessioned | 2020-08-12T11:54:59Z | |
| dc.date.available | 2020-08-12T11:54:59Z | |
| dc.date.issued | 2016-07 | |
| dc.date.submitted | 2016-06 | |
| dc.identifier.issn | 1948-5875 | |
| dc.identifier.uri | https://hdl.handle.net/1721.1/126533 | |
| dc.description.abstract | Traditional fragment-based drug discovery (FBDD) relies heavily on structural analysis of the hits bound to their targets. Herein, we present a complementary approach based on diversity-oriented synthesis (DOS). A DOS-based fragment collection was able to produce initial hit compounds against the target GSK3β, allow the systematic synthesis of related fragment analogues to explore fragment-level structure-activity relationship, and finally lead to the synthesis of a more potent compound. | en_US |
| dc.language.iso | en | |
| dc.publisher | American Chemical Society (ACS) | en_US |
| dc.relation.isversionof | 10.1021/ACSMEDCHEMLETT.6B00230 | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | PMC | en_US |
| dc.title | Diversity-Oriented Synthesis as a Strategy for Fragment Evolution against GSK3β | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Wang, Yikai et al. “Diversity-Oriented Synthesis as a Strategy for Fragment Evolution against GSK3β.” ACS medicinal chemistry letters, vol. 7, 2016, pp. 852-856 © 2016 The Author(s) | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
| dc.relation.journal | ACS medicinal chemistry letters | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dc.date.updated | 2020-03-11T17:51:16Z | |
| dspace.date.submission | 2020-03-11T17:51:19Z | |
| mit.journal.volume | 7 | en_US |
| mit.license | PUBLISHER_POLICY | |
| mit.metadata.status | Complete | |
