Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise
Author(s)
Song, H-H Greco; Rumma, Rowza T.; Edelman, Elazer R
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Although the clinical demand for bioengineered blood vessels continues to rise, current options for vascular conduits remain limited. The synergistic combination of emerging advances in tissue fabrication and stem cell engineering promises new strategies for engineering autologous blood vessels that recapitulate not only the mechanical properties of native vessels but also their biological function. Here we explore recent bioengineering advances in creating functional blood macro and microvessels, particularly featuring stem cells as a seed source. We also highlight progress in integrating engineered vascular tissues with the host after implantation as well as the exciting pre-clinical and clinical applications of this technology. Song et al. explore recent bioengineering advances in creating functional blood macro- and microvessels, particularly featuring stem cells as a seed source. They highlight progress in integrating engineered vascular tissues with the host after implantation as well as the exciting pre-clinical and clinical applications of this technology.
Date issued
2018-03Department
Massachusetts Institute of Technology. Institute for Medical Engineering & ScienceJournal
Cell stem cell
Publisher
Elsevier BV
Citation
Song, H-H Greco et al. “Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise.” Cell stem cell, vol. 22, no. 3, 2018, pp. 340-354 © 2018 The Author(s)
Version: Author's final manuscript
ISSN
1934-5909