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dc.contributor.authorEavri, Ronen
dc.contributor.authorShepherd, Jason Dennis
dc.contributor.authorWelsh, Christina A.
dc.contributor.authorFlanders, Genevieve
dc.contributor.authorBear, Mark
dc.contributor.authorNedivi, Elly
dc.date.accessioned2020-08-20T14:56:17Z
dc.date.available2020-08-20T14:56:17Z
dc.date.issued2018-08
dc.date.submitted2018-08
dc.identifier.issn0270-6474
dc.identifier.issn1529-2401
dc.identifier.urihttps://hdl.handle.net/1721.1/126704
dc.description.abstractChanges in excitatory neuron and synapse structure have been recognized as a potential physical source of age-related cognitive decline. Despite the importance of inhibition to brain plasticity, little is known regarding aging-associated changes to inhibitory neurons. Here we test for age-related cellular and circuit changes to inhibitory neurons of mouse visual cortex. We find no substantial difference in inhibitory neuron number, inhibitory neuronal subtypes, or synapse numbers within the cerebral cortex of aged mice compared with younger adults. However, when comparing cortical interneuron morphological parameters, we find differences in complexity, suggesting that arbors are simplified in aged mice. In vivo two-photon microscopy has previously shown that in contrast to pyramidal neurons, inhibitory interneurons retain a capacity for dendritic remodeling in the adult. We find that this capacity diminishes with age and is accompanied by a shift in dynamics from balanced branch additions and retractions to progressive prevalence of retractions, culminat-ingina dendritic arbor that is both simpler and more stable. Recording of visually evoked potentials shows that aging-related interneuron dendritic arbor simplification and reduced dynamics go hand in hand with loss of induced stimulus-selective response potentiation (SRP), a paradigm for adult visual cortical plasticity. Chronic treatment with the antidepressant fluoxetine reversed deficits in interneuron structural dynamics and restored SRP in aged animals. Our results support a structural basis for age-related impairments in sensory perception, and suggest that declines in inhibitory neuron structural plasticity during aging contribute to reduced functional plasticity.en_US
dc.description.sponsorshipNational Eye Institute (Grants RO1EY01756, RO1EY025437 and RO1EY023037)en_US
dc.description.sponsorshipNINDS (Grant K99-NS076364)en_US
dc.language.isoen
dc.publisherSociety for Neuroscienceen_US
dc.relation.isversionofhttp://dx.doi.org/10.1523/jneurosci.0808-18.2018en_US
dc.rightsCreative Commons Attribution 4.0 International licenseen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.sourceSociety for Neurocienceen_US
dc.titleInterneuron Simplification and Loss of Structural Plasticity As Markers of Aging-Related Functional Declineen_US
dc.typeArticleen_US
dc.identifier.citationEavri, Ronen et al. "Interneuron Simplification and Loss of Structural Plasticity As Markers of Aging-Related Functional Decline." Journal of Neuroscience 38, 39 (August 2018): 8421-8432. © 2018 The Author(s)en_US
dc.contributor.departmentPicower Institute for Learning and Memoryen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.relation.journalJournal of Neuroscienceen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2019-09-27T18:30:24Z
dspace.date.submission2019-09-27T18:30:27Z
mit.journal.volume38en_US
mit.journal.issue39en_US


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