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Gastrointestinal synthetic epithelial linings

Author(s)
LI, Junwei; Wang, Thomas; Shi, Yunhua; Jones, Alexis; Moussa, Zaina; Lopes, Aaron; Collins, Joy; Tamang, Siddartha M; Hess, Kaitlyn; Shakur, Rameen; Karandikar, Paramesh v; Lee, Jung Seung; Huang, Hen-Wei; Hayward, Alison M; Traverso, Carlo Giovanni; ... Show more Show less
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Abstract
Epithelial tissuesline the organs of the body, providing an initial protective barrieras well as a surface for nutrient and drug absorption. Here we identifiedenzymatic components present in the gastrointestinal epithelium that canserve as selective means for tissue-directed polymerization. We focusedon the small intestine, given its role in drug and nutrient absorption, and identified catalase as an essential enzyme with the potential to catalyze polymerization and growth of synthetic biomaterial layers. We demonstrated that the olymerization of dopamine by catalase yieldsstrong tissueadhesion. We characterizedthe mechanism and specificity of the polymerization in segments of the gastrointestinal tracts of pigs and human sex vivo. Moreover, we demonstrated proof-of-concept for application of these gastrointestinal synthetic epithelial linings(GSELs)for drug delivery, enzymatic immobilizationfor digestive supplementation, and nutritional modulation through transient barrier formationin pigs.This catalase-based approach to insitu biomaterial generationmay have broad indicationsfor gastrointestinal applications.
Date issued
2020
URI
https://hdl.handle.net/1721.1/126813
Department
Massachusetts Institute of Technology. Department of Chemical Engineering; Massachusetts Institute of Technology. Division of Comparative Medicine; Massachusetts Institute of Technology. Department of Mechanical Engineering; Koch Institute for Integrative Cancer Research at MIT
Journal
Science Translational Medicine
Publisher
American Association for the Advancement of Science
Citation
Li, Junwei et al. “Gastrointestinal synthetic epithelial linings.” Science Translational Medicine, 12, (2020) © 2020 The Author(s)
Version: Author's final manuscript
ISSN
1946-6242

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