Photo-Targeted Nanoparticles

Author(s)
Dvir, Tal; Banghart, Matthew R.; Timko, Brian P.; Langer, Robert S; Kohane, Daniel S.
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Abstract
We report a novel and simple proof-of-concept of a nanoparticulate system that targets any tissue selectively upon illumination. Nanoparticles were covalently functionalized with the amino acid sequence YIGSR, which adheres to the β1 integrins present on most cell surfaces. This peptide was masked with a caging group, rendering it biologically inert. Illumination with UV light released the caging group from the YIGSR, allowing binding to cells.
Date issued
2009-11
URI
https://hdl.handle.net/1721.1/127167
Department
Massachusetts Institute of Technology. Department of Chemical Engineering; Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Biological Engineering
Journal
Nano Letters
Publisher
American Chemical Society (ACS)
Citation
Dvir, Tal et al. "Photo-Targeted Nanoparticles." 10, 1 (January 2010): 250-254 © 2010 American Chemical Society
Version: Author's final manuscript
ISSN
1530-6984
1530-6992
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