Author(s)Dvir, Tal; Banghart, Matthew R.; Timko, Brian P.; Langer, Robert S; Kohane, Daniel S.
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We report a novel and simple proof-of-concept of a nanoparticulate system that targets any tissue selectively upon illumination. Nanoparticles were covalently functionalized with the amino acid sequence YIGSR, which adheres to the β1 integrins present on most cell surfaces. This peptide was masked with a caging group, rendering it biologically inert. Illumination with UV light released the caging group from the YIGSR, allowing binding to cells.
DepartmentMassachusetts Institute of Technology. Department of Chemical Engineering; Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Biological Engineering
American Chemical Society (ACS)
Dvir, Tal et al. "Photo-Targeted Nanoparticles." 10, 1 (January 2010): 250-254 © 2010 American Chemical Society
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