Osteophilic Multilayer Coatings for Accelerated Bone Tissue Growth

Author(s)
Shah, Nisarg J.; Hong, Jinkee; Hyder, Md Nasim; Hammond, Paula T
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Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/
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Abstract
Osteophilic modular nanostructured multilayers containing hydroxyapatite nanoparticles complexed with a natural polymer chitosan create an osteoconductive surface for mesenchymal stem cells (MSCs). Coupled with the sustained release of physiological amounts of osteoinductive bone morphogenetic protein over several days from degradable poly(β-amino ester) based multilayers, this single coating results in a synergistic accelerated and upregulated differentiation of MSCs into osteoblasts laying down new bone tissue on orthopedic implants. Copyright ©2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Date issued
2012-03
URI
https://hdl.handle.net/1721.1/127222
Department
Massachusetts Institute of Technology. Department of Chemical Engineering; Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies; Koch Institute for Integrative Cancer Research at MIT
Journal
Advanced Materials
Publisher
Wiley
Citation
Shah, Nisarg J. et al., "Osteophilic Multilayer Coatings for Accelerated Bone Tissue Growth." Advanced Materials 24, 11 (March 2012): 1445-50 doi. 10.1002/adma.201104475 ©2012 Authors
Version: Author's final manuscript
ISSN
1521-4095
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