Stability performance analysis of various packaging materials and coating strategies for chronic neural implants under accelerated, reactive aging tests

Author(s)
Gong, Yan; Liu, Wentai; Wang, Runyu; Brauer, Matthew Harris; Zheng, Kristine; ... Show more
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Abstract
ABSTRACT: Reliable packaging for implantable neural prosthetic devices in body fluids is a long-standing challenge for devices’ chronic applications. This work studied the stability of Parylene C (PA), SiO2, and Si3N4 packages and coating strategies on tungsten wires using accelerated, reactive aging tests in three solutions: pH 7.4 phosphate-buffered saline (PBS), PBS + 30 mM H2O2, and PBS + 150 mM H2O2. Different combinations of coating thicknesses and deposition methods were studied at various testing temperatures. Analysis of the preliminary data shows that the pinholes/defects, cracks, and interface delamination are the main attributes of metal erosion and degradation in reactive aging solutions. Failure at the interface of package and metal is the dominating factor in the wire samples with open tips. KEYWORDS: accelerated reactive aging test; long term; stability; packaging; implants; Parylene C; SiO2; Si3N4
Date issued
2020-08
URI
https://hdl.handle.net/1721.1/127763
Department
Massachusetts Institute of Technology
Journal
Micromachines
Publisher
Multidisciplinary Digital Publishing Institute
Citation
Gong, Yan et al. "Stability performance analysis of various packaging materials and coating strategies for chronic neural implants under accelerated, reactive aging tests." Micromachines 11, 9 (August 2020): 810 ©2020 Author(s)
Version: Final published version
ISSN
2072-666X
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